20.500.12556/DiRROS-31313 European experience on oncological outcomes of patients with early-stage non-small cell lung cancer and any prior cancer following lobectomy or segmentectomy Author links open overlay panel Objectives To assess the impact of lung resection extent on early-stage non-small cell lung cancer with a history of any cancer. Methods Retrospective multicentric cohort study including patients with ≤2 cm pathologic size lung cancer with a history of any cancer, operated on from 2015 to 2021 across nine European centers (one per country). Overall survival (OS), disease-free survival (DFS) and lung cancer specific death (LCSD) between both groups were assessed before and after propensity score (PS) −matching. Risk factors for oncologic outcomes were analyzed using parsimonious model cox proportional hazard regression. Kaplan Meier and cumulative incidence function assessed the outcomes. Log-rank test and Gray’ test compared the groups. Linearized risk was used to assess recurrences. Results Of the 1910 patients with early-stage lung cancer patients, 540 (28.2%) had a prior cancer. Lobectomy and segmentectomy were performed in 409 (75.7%) and 131 (24.3%) patients respectively. 5-year OS rates: lobectomy 81.5%, segmentectomy 80.8%, p = 0.8; DFS: lobectomy 76.9%, segmentectomy 74.4%, p = 0.6 and LCSD: lobectomy 8.0%, segmentectomy 4.9%, p = 0.2. These finding were similar in the matched cohort. Locoregional recurrence (linearized risk: lobectomy 0.111, segmentectomy 0.066) and distant recurrence (linearized risk: lobectomy 0.093, segmentectomy 0.055) were not worse in the segmentectomy group. In multivariable analysis, prior cancer negatively impacted only lung cancer specific death HR:1.27 (95%CI:1.00–1.60). Conclusion Compared to lobectomy, segmentectomy has not shown a worse oncologic outcome in patients with history of any prior cancer. segmentectomy cancer early-stage non-small lung canceroutcome true false true Angleški jezik Ni določen Neznano 2026-07-27 12:51:22 2026-07-27 12:51:23 2026-07-28 03:47:45 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 27. 5. 2026; str. 1-7 [article no.] 109410 Vol. 217 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 504.5 1872-8332 10.1016/j.lungcan.2026.109410 279560451 RAZ_Lula_Lukadi_Joseph_2026.pdf RAZ_Lula_Lukadi_Joseph_2026.pdf 1 8E3D7C945BBE39249400A7C03770128F 503b4c1d925ef26b96f923b3f168e875bdfdebf2e66ded17dfa67cec36290769 44284a4e-89a9-11f1-a255-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48410 https://www.sciencedirect.com/science/article/pii/S016950022600471X 1 1cb2a034-89a9-11f1-a255-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48409 Univerzitetni klinični center Ljubljana 0 0 0