20.500.12556/DiRROS-31125 Study protocol longitudinal observational study on frailty and mental health Introduction: Frailty is a dynamic condition associated with increased vulnerability to adverse health outcomes in older adults. While previous research has primarily focused on deficit-based mental health factors, such as depression and loneliness, less is known about the role of positive mental health determinants, including wellbeing, resilience and social connectedness, in the development and progression of frailty. Understanding both risk and protective factors is essential for informing public health strategies aimed at promoting healthy aging. This study aims to examine the longitudinal relationship between mental health and frailty in a nationally sampled population of adults aged 50 years and older in Slovenia.Methods and analysis: This longitudinal observational cohort study will collect data at four time points over a 2-year period (January 2026-March 2028). A stratified random sample of community-dwelling adults aged 50–84 years will be drawn from the national population registry, with 5,000 individuals invited to participate in the first wave. Frailty, mental health and a set of social, psychological, and health-related factors will be assessed. Data will be analyzed using a combination of descriptive, inferential and longitudinal statistical methods to examine associations between frailty and mental health over time. Potential explanatory factors will also be explored within the longitudinal framework, and additional analyses will assess the impact of attrition. 1 Introduction frailty adverse health outcomes older adults healthy aging krhkost starejši zdravo staranje neugodni zdravstveni izidi true false true Angleški jezik Slovenski jezik Neznano 2026-07-14 09:08:51 2026-07-14 09:08:51 2026-07-15 03:44:28 0000-00-00 00:00:00 2026 0 0 str. 1-6 Vol. 14 2026 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 2026-04-21 2026-06-17 2026-07-06 614 2296-2565 10.3389/fpubh.2026.1861495 284664323 https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1861495/full 1 deb80a71-7f52-11f1-b063-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47976 Nacionalni inštitut za javno zdravje 0 0 0