20.500.12556/DiRROS-30773 Trends and determinants of C virus infection among people living with HIV in Slovenia a nationwide study, 1986–2024 ntroduction: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share transmission routes and cause significant morbidity and mortality worldwide. Three previous nationwide studies reported a low prevalence of HCV infection among Slovenian people living with HIV (PLWH). Methods: Data were collected de novo from 526 PLWH newly diagnosed with HIV in Slovenia between January 1st, 2014, and December 31st, 2024, and combined with data from previous studies on this topic. Results: Altogether 1,085 (93%) PLWH were tested for HCV at HIV diagnosis: 82 (7.6%) had anti-HCV antibodies (49 or 59.8% of them viremic), and three had HCV RNA only, resulting in an HCV prevalence of 7.8%. A significant increase in the prevalence of HCV infection has been observed over the last decade. HCV infection was significantly associated with female sex, foreign nationality, parenteral HIV transmission route, and non-B HIV subtype. The most frequent HCV genotypes were 1 (60%), 3 (22%), and 4 (16%), markedly different than previously found in the general population. Conclusions: The overall prevalence of HCV infection among PLWH in Slovenia remains low, but a significant increase has been observed in the last decade compared to the previous one. Such a situation requires further regular and tight monitoring to allow timely interventions if and when needed. HIV hepatitis C prevalence Slovenia HIV hepatitis C obolevnost Slovenija true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Neznano 2026-07-02 11:10:03 2026-07-02 11:10:03 2026-07-03 03:46:48 0000-00-00 00:00:00 2026 0 Ljubljana 0 str. 33-36 iss. 1 Vol. 35 Mar. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-11-27 2026-01-23 2026-03-01 616.9 1318-4458 10.15570/actaapa.2026.2 277556739 actaapa.2026.2.pdf actaapa.2026.2.pdf 1 A056538DFDE57EEC7C06C052D75257F2 c545841c76e646c14dbe654ac7f3b72894bca0ad771437e764534efa8598b8c2 d03a180f-75f5-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47031 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2026.2/actaapa.2026.2.pdf 0 9d523683-75f7-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47033 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0