20.500.12556/DiRROS-30772 Giant cutaneous melanoma presenting with hemorrhagic complications Giant cutaneous melanoma is a rare presentation characterized by significant morbidity and mortality. We report the case of a 45-year-old male presenting with an acute life-threatening hemorrhage from a giant melanoma on his right thigh. The tumor, measuring 90 × 50 × 85 mm, was immediately excised under local anesthesia to achieve hemostasis. The patient exhibited acute anemia and required postoperative blood transfusion. Histopathological analysis confirmed superficial spreading melanoma with a Breslow thickness of 85.0 mm and extensive ulceration. Genetic testing identified critical mutations, including BRAFV600D and alterations involving the ARID2, CDKN2A/B, AKT3, PTEN, and HRAS genes. Remarkably, no metastatic disease was detected upon thorough diagnostic evaluation. The patient received adjuvant immunotherapy with programmed cell death-1 inhibitors. Six months after the procedure, he remains free of metastasis. This case underscores the urgent need for timely recognition and intervention in giant melanoma with acute complications. It also highlights the effectiveness of modern adjuvant therapies in improving prognosis. dermatologic surgery dermatopathology melanoma skin cancer dermatološka kirurgija dermatologija melanom rak kože true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-07-02 10:56:29 2026-07-02 10:59:04 2026-07-04 03:44:32 0000-00-00 00:00:00 2026 0 Ljubljana 0 Soavtorji: Ana Plesničar, Romi Cencelj-Arnež, Alenka Matjašič, Boštjan Luzar; str. 129-132 iss. 2 Vol. 35 Mar. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-04-02 2025-07-02 2026-03-01 617 1318-4458 10.15570/actaapa.2026.1 283158531 actaapa.2026.1.pdf actaapa.2026.1.pdf 1 20ADCDD157EB6A4083BF813C9A257552 e61c25e04c633447632d9110fabb2a486f2001f63ef5797b4e2312c1ca3a65e7 12c17bd5-76b6-11f1-852a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47056 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2026.1/actaapa.2026.1.pdf 0 896e05d1-75f4-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47029 Združenje slovenskih dermatovenerologov Univerzitetni klinični center Ljubljana Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0