20.500.12556/DiRROS-30699 Surgical resection of a giant hepatocellular carcinoma in an 89-year-old patient with multiple comorbidities the role of frailty assessment and preoperative optimisation : a case report and literature review Background and Clinical Significance: Liver cancer incidence increases with age, and surgical resection remains the primary curative option for early-to-intermediate hepatocellular carcinoma. In elderly patients, multimorbidity and frailty complicate risk assessment, so selection should consider more than chronological age. Case Presentation: An 89-year-old woman with hypertension, heart failure, atrial fibrillation on anticoagulation, and significant proximal LAD stenosis underwent preoperative percutaneous revascularisation and a left lateral sectionectomy for a solitary liver mass. Histology confirmed hepatocellular carcinoma; the early postoperative course required brief ICU support for haemodynamic instability and supplemental oxygen, with discharge on postoperative day six. Conclusions: This case report shows that, after multidisciplinary evaluation and targeted preoperative optimisation (including cardiac intervention), selected very elderly patients with multiple comorbidities may be considered for liver resection, though they remain at increased risk of perioperative cardiopulmonary and haemodynamic events. Incorporating frailty, nutritional, and functional assessments alongside comorbidity profiling improves patient selection and supports individualised decision-making. hepatectomy carcinoma hepatocellular frailty perioperative care comorbidity multidisciplinary team heatektomija krhkost multidisciplinarni tim true false true Angleški jezik Slovenski jezik Neznano 2026-07-01 10:48:26 2026-07-01 10:48:27 2026-07-03 03:46:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 6. 2026; str. 1-20 issue 12, [article no.] 1902 Vol. 16 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617 2075-4418 10.3390/diagnostics16121902 282272259 RAZ_Krnojelac_Milan_2026.pdf RAZ_Krnojelac_Milan_2026.pdf 1 D1350809715D5D98649AF29AC60BBAA2 48a777216e5595cb066018214d8db8d30046cfa0cea8274e872677306692ed75 a166b312-75f8-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47034 https://www.mdpi.com/2075-4418/16/12/1902 1 a14242eb-7529-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46828 Univerzitetni klinični center Ljubljana 0 0 0