20.500.12556/DiRROS-30696 Dyslipidemia and retinal microvascular health in children and adolescents a systematic review Background/Objectives: Dyslipidemia is increasingly linked to retinal microvascular changes, yet its impact in pediatric populations remains unclear. Given the retina’s role as a microvascular model, this review evaluates the association between dyslipidemia and retinal vascular alterations in children and adolescents. Methods: We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines to evaluate the association between lipid profiles, body composition, and retinal vascular parameters in individuals younger than 19 years. Four eligible studies were found. Results: Triglyceride (TG) levels, total cholesterol (TC) levels, low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apoB) levels were associated with smaller retinal arteriole diameters (CRAE), whereas there was no consistent association between venular diameter (CRVE) and lipid levels. In addition, families with familial hypercholesterolemia (FH) had lower capillary densities and larger foveal avascular zone areas detected by optical coherence tomography angiography (OCT-A) compared to control subjects. The presence of both obesity and dyslipidemia resulted in greater degrees of arteriolar narrowing. Conclusions: These findings suggest that adverse metabolic profiles in childhood may be linked to early microvascular alterations. However, the limited number of heterogeneous studies highlights the need for larger longitudinal investigations. body composition dyslipidemia retinal vessels children familial hypercholesterolemia optical coherence tomography angiography true false true Angleški jezik Ni določen Neznano 2026-07-01 10:39:12 2026-07-01 10:39:13 2026-07-03 03:46:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 17. 6. 2026; 12 str. issue 6, [article no.] 824 Vol. 13 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 2227-9067 10.3390/children13060824 281984003 RAZ_Xhafa_Krenar_2026.pdf RAZ_Xhafa_Krenar_2026.pdf 1 5D43275ED6402D863D0F7BE97A93E8F9 2cdb6c13591feaf5eadee0f3c5bfa49cadb994a6139ecdfaf937bb7c7346c38e dd8f4bd3-75f9-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47035 https://www.mdpi.com/2227-9067/13/6/824 1 57280c1d-7528-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46776 Univerzitetni klinični center Ljubljana 0 0 0