20.500.12556/DiRROS-30689 Kidney replacement therapy trajectories of patients with kidney failure an ERA Registry study Background: Trajectories of patients receiving kidney replacement therapy (KRT), including transitions between hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx), may vary across patient sub-groups and have not yet been investigated in Europe. This study aimed to: (1) describe the number of shifts across KRT modalities; and (2) characterize the most frequent patient trajectories, including the direction of shifts across KRT modalities, the duration spent on each modality, and patient events, including death. Methods: Data of adult patients (≥20 years) who initiated KRT between 2004-2013 were extracted from the European Renal Association (ERA) Registry database and patients were followed for 10 years from the moment of KRT initiation. Results were stratified by age, sex, primary renal disease (PRD), country, and initial KRT modality. Results: Among 289,323 patients, more than two-thirds (69.6%) remained on their initial KRT modality until death or the end of 10 years follow-up, but younger patients and patients who initiated with PD had more shifts across KRT modalities than others. Overall, the most frequent patient trajectories were HD followed by death (53.4%), HD to KTx (10.2%), remaining on HD for 10 years (5.6%), PD followed by death (4.4%), and PD to KTx (2.9%). The most frequent patient trajectories differed between age and PRD groups, and across European countries, but not between women and men. Conclusion: The number and direction of shifts across KRT modalities varied by age, PRD, country, and initial KRT modality, but not by sex. Future research should further investigate trajectories of patient sub-groups that stood out, including young HD patients who died on their initial KRT modality and those who remained on HD for 10 years without undergoing KTx. haemodialysis kidney transplantation peritoneal dialysis modalities true false false Angleški jezik Ni določen Neznano 2026-07-01 10:11:46 2026-07-01 10:11:46 2026-07-02 03:59:40 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 11. 2025; str. 1105–1117 iss. 6 Vol. 41 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 1460-2385 10.1093/ndt/gfaf236 258744835 RAZ_Boerstra_Brittany_A._2026.pdf RAZ_Boerstra_Brittany_A._2026.pdf 1 5508AEDE6E1CEB392BCED481CCCFE79E a9515dfc93303c291e4e7121c4436b006c6a16222361b90c657c1f97864ce5b0 9bc1850b-7524-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46758 https://academic.oup.com/ndt/article/41/6/1105/8313648 1 81f7ccf0-7524-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46757 Univerzitetni klinični center Ljubljana 0 0 0