20.500.12556/DiRROS-30676 Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia Behavioral variant of frontotemporal dementia (bvFTD) is common among young-onset dementia patients. While bvFTD-specific multivariate metabolic brain pattern (bFDRP) has been identified previously, little is known about its temporal evolution, internal structure, effect of atrophy, and its relationship with nonspecific resting-state networks such as default mode network (DMN). In this multicenter study, we explored FDG-PET brain scans of 111 bvFTD, 26 Alzheimer's disease, 16 Creutzfeldt-Jakob's disease, 24 semantic variant primary progressive aphasia (PPA), 18 nonfluent variant PPA and 77 healthy control subjects (HC) from Slovenia, USA, and Germany. bFDRP was identified in a cohort of 20 bvFTD patients and age-matched HC using scaled subprofile model/principle component analysis and validated in three independent cohorts. It was characterized by hypometabolism in frontal cortex, insula, anterior/middle cingulate, caudate, thalamus, and temporal poles. Its expression in bvFTD patients was significantly higher compared to HC and other dementia syndromes (p < .0004), correlated with cognitive decline (p = .0001), and increased over time in longitudinal cohort (p = .0007). Analysis of internal network organization by graph-theory methods revealed prominent network disruption in bvFTD patients. We have further found a specific atrophy-related pattern grossly corresponding to bFDRP; however, its contribution to the metabolic pattern was minimal. Finally, despite the overlap between bFDRP and FDG-PET-derived DMN, we demonstrated a predominant role of the specific bFDRP. Taken together, we validated the bFDRP network as a diagnostic/prognostic biomarker specific for bvFTD, provided a unique insight into its highly reproducible internal structure, and proved that bFDRP is unaffected by structural atrophy and independent of normal resting state networks loss. nevrologija demenca radiologija FDG-PET SSM/PCA true false true Angleški jezik Slovenski jezik Neznano 2026-07-01 09:16:28 2026-07-01 09:16:29 2026-07-02 03:59:38 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 27. 6. 2023; str. 1079-1093 iss. 3 Vol. 44 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1097-0193 10.1002/hbm.26140 130194947 RAZ_Rus_Tomaz_2023.pdf RAZ_Rus_Tomaz_2023.pdf 1 748E7FAEF1A8957557F0D97F0BECC816 75c6b26ce3d26d25dc24acbeeb6e382a08476d5dc88ae42f88be4468c18a0cdc f18fe603-751c-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46727 https://onlinelibrary.wiley.com/doi/10.1002/hbm.26140 1 c8123632-751c-11f1-b0d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46726 Univerzitetni klinični center Ljubljana 0 0 0