20.500.12556/DiRROS-30631 Transition from parenteral to subcutaneous application of systemic oncological therapy for treating non-small-cell lung cancer Background: The transition from the parenteral to subcutaneous application of systemic oncological therapy represents one of the most important innovations in modern oncology, as it affects the quality of life of patients as well as the organization of work and the management of health services. The introduction of this change requires effective leadership, interdisciplinary cooperation, and the adaptation of existing processes in healthcare organizations. Methods: We conducted a systematic review of the professional and scientific literature, considering the purpose and goal of this research. We used electronic databases: Wiley Online Library, PubMed, COBBIS.SI, and Google Scholar web browser. Papers from 2017 to 2025 were considered and processed using meta-synthesis. Results: Recent studies confirm that the subcutaneous administration of immunotherapy and targeted therapy is as effective and safe as parenteral immunotherapy, while significantly reducing treatment time and improving patient experience. Discussion: The transition to subcutaneous application provides an opportunity to transform oncology care. From a management perspective, the introduction of subcutaneous application requires systematic change management, staff training, process adaptation, and interdisciplinary cooperation. The sustainable implementation of innovations depends on organization, communication, and management support. lung cancer oncological therapy quality of medical treatment pljučni rak onkološka terapija kakovost zdravstvene obravnave true false true Multimed Current oncology Angleški jezik Slovenski jezik © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. Neznano 2026-06-30 11:24:25 2026-06-30 11:24:25 2026-07-01 03:56:03 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 6. 2026; 10 str. issue 6 Vol. 33 Jun 2026 0000-00-00 Zaloznikova Objavljeno apc 2026-03-24 2026-05-23 2026-05-25 616.24-006-083 1718-7729 10.3390/curroncol33060307 280076547 RAZ_Muratovic_Anela_2026.pdf RAZ_Muratovic_Anela_2026.pdf 1 407C9EE231981A8B796087A525AAF0EC b8c5cdca4df8d47ebc8cf45af4a789c04a8edb0ce2b788f2e5b02230e2d0d264 007ae8e3-7466-11f1-9c8b-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46643 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0