20.500.12556/DiRROS-30468 Role of endoscopic ultrasound-guided fine needle aspiration biopsies in diagnosing pancreatic neoplasms in the paediatric population experience from a tertiary center and review of the literature Vloga endoskopskih ultrazvočno vodenih aspiracijskih biopsij s tanko iglo v diagnostiki neoplazem trebušne slinavke pri pediatrični populaciji Background: Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS FNAB) is a well established diagnostic method in adult patients, but is rarely used in the paediatric population. The Clinical Department of Gastroenterology at the University Clinical Centre Ljubljana and the Department of Cytopathology at the Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia, have been closely collaborating on EUS FNAB since the introduction in 2010. The aim of the study was to review the cases of EUS FNAB of pancreatic neoplasms in children. Patients and methods: In the digital archive of the Institute of Pathology (IP), Faculty of Medicine (FM), University of Ljubljana (UL), we found 6 cases of EUS FNAB in children, 3 had EUS FNAB of the pancreas, 2 of whom had a cytopathologic diagnosis of a tumour. In the first case, the lesion was ultrasonographically solid, and the cell sample contained branching papillary structures surrounded by aggregates of small cells with nuclear grooves. In the second case, the lesion was ultrasonographically cystic, and predominantly necrosis was seen, with only single preserved cells. Positive nuclear reaction for β-catenin was found in both cases by immunohistochemical staining. Results: In both cases, the cytopathological diagnosis of solid pseudopapillary neoplasm of the pancreas was made, the cases represent the totality of paediatric cases of pancreatic neoplasms from the Children's Hospital Ljubljana since 2010. There were no adverse events during and after EUS FNAB. A histopathological examination of the tumour resection specimens confirmed the cytopathological diagnosis. Conclusions: Our experience indicates that EUS FNAB is a safe and effective method for diagnosing pancreatic neoplasms in the pediatric population, as supported by the findings in the literature. fine needle aspiration biopsy endoscopic ultrasound pancreatic neoplasm paediatric pathology aspiracijska biopsija s tanko iglo endoskopski ultrazvok neoplazma trebušne slinavke otroška patologija true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik Neznano 2026-06-26 14:01:32 2026-06-26 14:01:32 2026-06-27 03:52:15 0000-00-00 00:00:00 2024 0 0 Soavtorji: Jernej Brecelj, Andrej Gruden, Margareta Strojan Flezar; str. 78-86, VIII no. 1 Vol. 58 Mar. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2024-03-01 616-006 1318-2099 10.2478/raon-2024-0008 187193091 https://sciendo.com/article/10.2478/raon-2024-0008 1 c732ed21-7156-11f1-b414-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46272 RAZ_Kebe_Radulovic_Maja_2024.pdf RAZ_Kebe_Radulovic_Maja_2024.pdf 1 43F4B4EE15D4D68F4E97DD84929CB50F 1460f250eca484c779cafb911a15fa0dbc504abcc9244f51b06a858823710ceb dd941191-7156-11f1-b414-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46273 Društvo radiologije in onkologije 0 0 0