20.500.12556/DiRROS-30467 The initial results of MRI-TRUS fusion prostate biopsy in high volume tertiary center Začetni rezultati fuzijske biopsije prostate z magnetno resonanco in transrektalnim ultrazvokom (MRI-TRUZ) v večji terciarni ustanovi Background: Multiparametric magnetic resonance imaging (mpMRI) is a prerequisite for targeted prostate biopsy. The aim of our study was to evaluate the performance and learning curve of the mpMRI-transrectal ultrasound (TRUS) software image fusion (MRI-TRUS fusion) biopsy (BX) process in the first year after its introduction in our urology department. Patients and methods: MRI-TRUS fusion BX was performed in 293 patients with at least one Prostate Imaging-Reporting and Data System (PIRADS) ≥3 lesion. The proportion of patients and lesions with positive histopathologic result for prostate cancer (PCa) was analyzed. The learning curve for MRI-TRUS fusion BX was assessed at institutional and individual level. Positive BX lesions were further analyzed by PIRADS and Gleason scores. Results: The proportion of patients with positive histopathologic results for targeted BX, systematic BX, and combined BX was 53.9%, 47.9%, and 63.5%, respectively. The chi-square test for the proportion of PCa positive patients showed no significant difference between the time-based patient groups at the institutional level and no significant difference between individual urologists. PIRADS score (p < 0.001), total PSA concentration (p = 0.05), prostate volume (p < 0.001) and number of cores per lesion (p = 0.034) were significant predictors of a positive histopathologic result in a lesion-based analysis. Clinically significant PCa (csPCa) was confirmed in 34.7% of the 412 BX lesions and 76.4% of the 187 positive PCa lesions. Conclusions: MRI-TRUS fusion targeted BX significantly improves the overall rate of PCa detection compared with systematic BX alone. No steep learning curve was observed in our urologists. The proportion of lesions with clinically insignificant PCa was low, limiting overdiagnosis of PCa. complications learning curve prostate cancer targeted prostate biopsy komplikacije krivulja učenja rak prostate ciljana biopsija prostate true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik Neznano 2026-06-26 13:58:52 2026-06-26 13:58:53 2026-06-27 03:52:14 0000-00-00 00:00:00 2024 0 0 Soavtorji: Milena Taskovska, Iztok Ditz, Klemen Cernelc, Simon Hawlina; str. 501-508, V no. 4 Vol. 58 Dec. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2024-12-01 616-006:616.6 1318-2099 10.2478/raon-2024-0060 219762435 https://www.radioloncol.com/index.php/ro/article/view/4490/5269 1 678ac2fe-7156-11f1-b414-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46270 RAZ_Smrkolj_Tomaz_2024.pdf RAZ_Smrkolj_Tomaz_2024.pdf 1 BFC894FB2D9AE163E961FBB2C13D73D2 8bc7a54f4b61bea71cf68a75cfb519d4834cd0271ba5515e48a6d46a904e17e4 9e1735da-7156-11f1-b414-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46271 Društvo radiologije in onkologije 0 0 0