20.500.12556/DiRROS-30453 Determination of copper and other trace elements in serum samples from patients with biliary tract cancers prospective noninterventional nonrandomized clinical study protocol Določanje bakra in drugih elementov v sledovih v serumskih vzorcih bolnikov z raki biliarnega trakta Background Biliary tract cancers (BTCs) are usually diagnosed at an advanced stage, when the disease is incurable. Currently used tumor biomarkers have limited diagnostic value for BTCs, so there is an urgent need for sensitive and specific biomarkers for their earlier diagnosis. Deregulation of the homeostasis of trace elements is involved in the carcinogenesis of different cancers, including BTCs. The objective of the study is to determine/compare the total concentrations of copper (Cu), zinc (Zn) and iron (Fe) and the proportions of free Cu and Cu bound to ceruloplasmin (Cp) and the isotopic ratio of 65Cu/63Cu in serum samples from healthy volunteers and cancer patients using inductively coupled plasma-mass spectrometry-based methods (ICP-MS). trace elements copper predictive biomarkers of response baker biomarkerji rak true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik Neznano 2026-06-26 10:12:19 2026-06-26 10:12:20 2026-06-27 03:52:12 0000-00-00 00:00:00 2024 0 0 str. 300-310, XIV no. 2 Vol. 58 Jun. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2024-06-01 54 1318-2099 10.2478/raon-2024-0026 192145667 RAZ_Rebersek_Martina_2024.pdf RAZ_Rebersek_Martina_2024.pdf 1 C598D8AEF1EC48730E8CE3211BC57A6A 06bff01a13539c220c43965ff4ecb6b9e2934c5b1944aace6adcd429ea4bbdb0 fc25ae46-7136-11f1-b414-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46248 Društvo radiologije in onkologije Onkološki inštitut Ljubljana 0 0 0