20.500.12556/DiRROS-30431 Pathogenesis and potential reversibility of intestinal metaplasia − a milestone in gastric carcinogenesis Patogeneza in potencialna reverzibilnost intestinalne metaplazije-mejnik v karconogenzi želodca Background. Non-cardia gastric cancer remains a major cause of cancer-related mortality worldwide, despite declining incidence rates in many industrialized countries. The development of intestinal-type gastric cancer occurs through a multistep process in which normal mucosa is sequentially transformed into hyperproliferative epithelium, followed by metaplastic processes leading to carcinogenesis. Chronic infection with Helicobacter pylori is the primary etiological agent that causes chronic inflammation of the gastric mucosa, induces atrophic gastritis, and can lead to intestinal metaplasia and dysplasia. Both intestinal metaplasia and dysplasia are precancerous lesions, in which gastric cancer is more likely to occur. Atrophic gastritis often improves after eradication of Helicobacter pylori; however, the occurrence of intestinal metaplasia has been traditionally regarded as “the point of no return” in the carcinogenesis sequence. Helicobacter pylori eradication heals non-atrophic chronic gastritis, may lead to regression of atrophic gastritis, and reduces the risk of gastric cancer in patients with these conditions. In this article, we discuss the pathogenesis, epigenomics, and reversibility of intestinal metaplasia and briefly touch upon potential treatment strategy. Conclusions. Gastric intestinal metaplasia no longer appears to be an irreversible precancerous lesion. However, there are still many controversies regarding the improvement of intestinal metaplasia after Helicobacter pylori eradication Helicobacter pylori intestinal metaplasia gastric cancer true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik Neznano 2026-06-24 14:27:46 2026-06-24 14:27:46 2026-06-25 03:51:32 0000-00-00 00:00:00 2024 0 0 Soavtorji: Matjaž Homan, Nina Zidar, Lojze M Smid; str. 186-195, III iss. 2 Vol. 58 Jun. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2024-06-01 61 1318-2099 10.2478/raon-2024-0028 200321027 https://sciendo.com/article/10.2478/raon-2024-0028 1 1c8abb3f-6fc8-11f1-98c5-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46189 RAZ_Drnovsek_Jan_2024.pdf RAZ_Drnovsek_Jan_2024.pdf 1 236D1CD6CA183A3CAB63C4C75AF7F47C 62fe191b28c1c2cf7f3c06bf7b5417ef86662cf1839b9e1d04b394dc2b4d0825 4be64cf7-6fc8-11f1-98c5-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46191 Društvo radiologije in onkologije 0 0 0