20.500.12556/DiRROS-30278 Clinical impact of trace elements as potential biomarkers for diagnosis and prediction of response to systemic treatment in gastrointestinal cancers Gastrointestinal cancers are among the most common malignancies worldwide and, at advanced stages, remain incurable. Currently used biomarkers, such as tumour markers, have limited diagnostic value for early detection and relapse, highlighting the urgent need for more sensitive and specific markers. Trace elements are involved in numerous physiological and metabolic processes, and deregulation of their homeostasis is implicated in the carcinogenesis of various cancers, including gastrointestinal malignancies. Several basic and preclinical studies have identified the importance of trace elements in key biological processes. Recent clinical studies and retrospective analyses suggest that fluctuations in trace element levels may be associated with the development and progression of many cancers. Thus, quantitative and dynamic determination of serum trace element concentrations during treatment and follow-up represents a promising option for monitoring treatment efficacy and disease prognosis. Conclusions. Trace elements may serve as potential prognostic and predictive biomarkers for diagnosis and response to systemic treatment. gastrointestinal cancers systemic therapy prognostic and predictive biomarkers trace elements rak prebavil sistemsko zdravljenje prognostični in napovedni biološki označevalci sledi elementov true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik Neznano 2026-06-18 10:42:48 2026-06-18 10:42:48 2026-06-19 03:51:59 0000-00-00 00:00:00 2026 0 0 str. [1-6] no. Vol. 60 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2026-01-01 616.3 1318-2099 10.2478/raon-2026-0023 275564291 RAZ_Rebersek_Martina_2026.pdf RAZ_Rebersek_Martina_2026.pdf 1 768C961280640CEAFD87FDE2D00F2E3E b3f1cc44bceeecdd38140916c243955512e72ac214f00a7ed472bbd09dd48b21 716ec8b1-6ae9-11f1-be3d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45897 Društvo radiologije in onkologije Onkološki inštitut Ljubljana 0 0 0