20.500.12556/DiRROS-30213 Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest BRAVE study Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study Artificial gravity (AG) combined with resistive vibration exercise has been proposed as a multi-system countermeasure for long-duration spaceflight; however, its operational feasibility during prolonged unloading remains insufficiently characterised. This study primarily evaluated the feasibility, tolerability, and adherence to a structured resistive vibration exercise protocol delivered either under artificial gravity (AGRVE) or in horizontal loading (HRVE) during 60 days of hypoxic (F[sub](IO2) = 0.14) 6° head-down tilt bed rest. Secondary observations included delayed-onset muscle soreness (DOMS) and changes in eight-repetition maximum strength (8RM) to inform load progression. Sixteen healthy male participants were allocated to HRVE (n = 9) or AGRVE (n = 8) and completed near-daily 30-min training sessions at light (30% 1RM) and moderate (50% 1RM) intensities. Adherence was high in both groups (HRVE: 98.5%; AGRVE: 96.3%). In AGRVE, early-session interruptions were primarily due to motion sickness or presyncopal symptoms; motion sickness severity declined significantly across repeated centrifugation exposures (P < 0.001), consistent with vestibular habituation. HRVE interruptions were predominantly fatigue-related. DOMS remained low throughout the intervention (typically 0–3/10). 8RM increased over time in both groups (P < 0.001). Progressive resistive vibration exercise can be implemented with high adherence during prolonged hypoxic bed rest, including when combined with AG. Motion sickness represents the principal early operational constraint specific to squat-based AG exposure but diminishes with repeated sessions. artificial gravity resistive vibration exercise exercise physiology umetna gravitacija vadbena fiziologija bivanje v vesolju true false true Published by John Wiley & Sons Ltd on behalf of The Physiological Society. Angleški jezik Slovenski jezik © The Author(s). Neznano 2026-06-17 14:15:58 2026-06-17 14:15:59 2026-06-18 04:07:45 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Sara Podgornik, Urša Ciuha, Igor B. Mekjavič; Opis vira z dne 17. 6. 2026; str. 1-21 iss. Vol. 111 [in press] 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-01-23 2026-03-09 2026-05-28 612 1469-445X 10.1113/EP093699 281903875 https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP093699 1 4e3a72ca-6a46-11f1-97b2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45774 RAZ_Fortune_Jack_2026.pdf RAZ_Fortune_Jack_2026.pdf 1 9FD5FB233E7AF74321D146858D23BA05 6f25df4ae15fae2b095aea7f09ee3e7bd8946573bfe01fba71118db9a42b2a8e 1aa579d2-6a47-11f1-97b2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45775 Institut Jožef Stefan 0 0 0