20.500.12556/DiRROS-30118 Why is the duration of erythema migrans at diagnosis longer in patients with lyme neuroborreliosis than in those without neurologic involvement? In prior studies, the skin lesion erythema migrans (EM) was present for a longer time period before diagnosis of concomitant borrelial meningoradiculoneuritis (Bannwarth’s syndrome) compared to EM patients without neurologic symptoms. To determine if this observation pertains to other manifestations of Lyme neuroborreliosis (LNB), we compared EM characteristics in patients with borrelial meningoradiculoneuritis (n = 122) to those with aseptic meningitis without radicular pain (n = 72 patients), and to patients with EM but without neurologic involvement (n = 12,384). We also assessed factors that might impact duration. We found that the duration of EM at diagnosis in patients with borrelial meningoradiculoneuritis was not significantly different compared with those with LNB without radicular pain (34 vs. 26 days; p = 0.227). The duration of EM for each of these clinical presentations of LNB, however, was significantly longer than in patients with EM without LNB (10 days; p < 0.001). Contributing factors to this difference might have been that patients with LNB failed to recognize that they had EM or were unaware of the importance of not delaying antibiotic treatment for EM. In conclusion, the duration of the EM skin lesion in EM patients with LNB is longer than in patients with just EM, irrespective of the type of LNB. lyme borreliosis lyme disease erythema migrans Bannwarth’s syndrome borrelial meningoradiculoneuritis true false true Angleški jezik Ni določen Neznano 2026-06-15 14:55:43 2026-06-15 14:55:43 2026-06-16 03:54:52 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 2. 2024; str. 1-10 no. 2, [article no.] 137 Vol. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 2076-0817 10.3390/pathogens13020137 186822915 RAZ_Ogrinc_Katarina_2024.pdf RAZ_Ogrinc_Katarina_2024.pdf 1 F472C3977ABA3CD6C105F1786A88EB2F 191484d3f46eb803eebad46df15d7221051df4695a7254ee73743da10862634a ba36310f-68b9-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45484 https://www.mdpi.com/2076-0817/13/2/137 1 86db3709-68b9-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45483 Univerzitetni klinični center Ljubljana 0 0 0