20.500.12556/DiRROS-30112 The outcome of metabolic and bariatric surgery in morbidly obese patients with different genetic variants associated with obesity a systematic review Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities, though individual responses vary. This systematic review examines how genetic variants influence MBS outcomes in morbidly obese patients. A comprehensive search in PubMed, Embase, Medline, and the Cochrane Library identified 1572 studies, with 52 meeting the inclusion criteria. Two reviewers independently filtered and selected studies, including relevant cross-references. Research focused on polymorphisms in genes such as UCP2, UCP3, 5-HT2C, MC4R, FKBP5, FTO, CAT haplotypes, LYPAL-1, PTEN, FABP-2, CNR1, LEP656, LEP223, GLP-1R, APOA-1, APOE, ADIPOQ, IL-6, PGC1a, TM6SF2, MBOAT7, PNPLA3, TCF7L2, ESR1, GHSR, GHRL, CD40L, DIO2, ACSL5, CG, TAS2R38, CD36, OBPIIa, NPY, BDNF, CLOCK, and CAMKK2. Most studies explored associations with post-surgery weight loss, while some examined metabolic, cardiovascular, taste, and eating behavior effects as well. Understanding the role of genetic factors in weight loss and metabolic outcomes post-MBS can help tailor personalized treatment plans for improved efficacy and long-term success. Further research with larger sample sizes and extended follow-up is needed to clarify the effects of many genetic variants on MBS outcomes in morbidly obese patients. obesity morbid obesity metabolic and bariatric surgery genetic variant polymorphism single nucleotide polymorphism debelost morbidna debelost presnovna in bariatrična kirurgija genetska različica polimorfizem enojni nukleotidni polimorfizem true false true Angleški jezik Slovenski jezik Neznano 2026-06-15 14:28:05 2026-06-15 14:28:05 2026-06-16 03:54:51 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 5. 8. 2024; str. 1-24 iss. 15, [article no.] 2510 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 2072-6643 10.3390/nu16152510 203541763 RAZ_Zafirovska_Marija_2024.pdf RAZ_Zafirovska_Marija_2024.pdf 1 5B16EA591E8CAB1057306AC60F9B2964 7339093f2283a4e1c7a8aa708874e311a0383ac3e58eed1580d76d51463891d8 cace79ff-68b5-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45473 https://www.mdpi.com/2072-6643/16/15/2510 1 aa35df13-68b5-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45471 Univerzitetni klinični center Ljubljana 0 0 0