20.500.12556/DiRROS-30102 Effect of biological therapy on symptom burden and functional disability in patients with migraine a before-and-after analysis Vpliv biološkega zdravljenja na simptomsko obremenitev in funkcionalno prizadetost pri bolnikih z migreno pre–post analiza Introduction This study aims to assess the effectiveness of biological therapies in reducing migraine-related symptom burden and functional disability, including reductions in monthly migraine days, pain intensity, and analgesic consumption, among patients with migraine in Slovenia. Methods This retrospective study analysed 92 adult patients with migraine receiving prophylactic biological treatment at the University Medical Centre Ljubljana. Average number of monthly migraine days (MMD), average analgesic consumption, pain intensity (VAS), and functional disability score (MIDAS) were collected before treatment and after 3 and 12 months. Statistical analysis involved the Friedman test to assess changes over time, followed by Wilcoxon tests with Bonferroni correction for post hoc comparisons. Results 83 patients completed 12 months of treatment. Significant reductions (p < 0.001) were observed in MMD (median 10 vs. 2 days), analgesic consumption, VAS scores (median 8 vs. 4), and MIDAS scores after 3 months (median 19 vs. 2), sustained at 12 months. Treatment discontinuation occurred in 9 patients due to inefficacy or side effects. Most patients tolerated biologics well, with mild adverse effects reported. Conclusions Biological therapies significantly reduced migraine-related symptom burden and functional disability, including decreases in migraine frequency, pain intensity, and analgesic use, in a Slovenian migraine cohort. These findings support the use of biologics as effective and safe options for migraine prevention in real-world clinical practice. monoclonal antibodies neurology disability evaluation preventive treatment monoklonska protitelesa nevrologija ocenjevanje invalidnosti preventivno zdravljenje true false true Angleški jezik Slovenski jezik Neznano 2026-06-15 13:54:11 2026-06-15 13:54:11 2026-09-07 22:29:25 0000-00-00 00:00:00 2026 0 0 Besedilo v angl.; str. 34-40 no. 1 Vol. 65 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2025-08-20 0000-00-00 616.857 0351-0026 10.2478/sjph-2026-0005 270641411 Effect_of_Biological_Therapy_on_Symptom_Burden_and_Functional_Disability_in_Patients_with_Migraine_A.pdf Effect_of_Biological_Therapy_on_Symptom_Burden_and_Functional_Disability_in_Patients_with_Migraine_A.pdf 1 2BB9C12AD035AC58FC48FC9A85C679BC f7d77d4c8596db7e4ca382e63aac3c580c30b16838733e645710e2c43b82d8a3 34b34bfa-68b1-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45452 https://reference-global.com/article/10.2478/sjph-2026-0005 1 53f778e1-76cd-11f1-852a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47071 Nacionalni inštitut za javno zdravje Univerzitetni klinični center Ljubljana Slovenian journal of public health 0 0 0