20.500.12556/DiRROS-30061 Microbiologic findings in a cohort of patients with erythema migrans Erythema migrans (EM) is the initial and the most frequent clinical manifestation of Lyme borreliosis (LB). Herein, we report on the capacity of culture and serology for the demonstration of Borrelia infection in a cohort of 292 patients diagnosed with typical EM at a single medical center. The median duration of EM at diagnosis was 12 days, and the largest diameter was 16 cm; 252 (86.3%) patients presented with solitary EM, whereas 40 (13.7%) had multiple EM. A total of 95/292 (32.5%) patients had positive IgM, and 169 (57.9%) had positive IgG serum antibodies; the Borrelia isolation rate was 182/292 (62.3%). The most frequent species by far was B. afzelii (142/148, 95.9%) while B. garinii (2.7%) and B. burgdorferi s.s. (1.4%) were rare. IgM seropositivity was associated with a younger age, multiple EM and the absence of underlying chronic illness; IgG seropositivity was associated with the duration of EM at diagnosis, the diameter of the EM, having had a previous episode of LB and the absence of symptoms at the site of the EM. Furthermore, the Borrelia isolation rate was statistically significantly lower in patients with positive Borrelia IgM antibodies. Although microbiologic analyses are not needed for the diagnosis of typical EM, they enable insights into the etiology and dynamics of the immune response in the course of early LB. erythema migrans Lyme borreliosis Borrelia afzelii culture serology migrirajoči eritem Lyme borreliosis Borrelia afzelii kultura serologija true false true Angleški jezik Slovenski jezik Neznano 2026-06-12 13:22:52 2026-06-12 13:22:52 2026-06-13 03:52:16 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 31. 1. 2024; str. 1-10 iss. 1, [article no.] 185 Vol. 12 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61:579 2076-2607 10.3390/microorganisms12010185 183169027 RAZ_Ruzic-Sabljic_Eva_2024.pdf RAZ_Ruzic-Sabljic_Eva_2024.pdf 1 78D42796184F4D86B0E69FC4C6967645 0a399c35618070283ac548db73aa316d44923cbfc604f68e2a8417e0dd7e2962 2c97c039-6651-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45345 https://www.mdpi.com/2076-2607/12/1/185 1 0e4e9cfa-6651-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45344 Univerzitetni klinični center Ljubljana 0 0 0