20.500.12556/DiRROS-30027 Long-term infection with a particular human papillomavirus (HPV) genotype, HPV Subtype, or HPV genomic variant does not significantly influence the clinical course of recurrent Respiratory Papillomatosis Recurrent respiratory papillomatosis (RRP) is caused by human papillomaviruses (HPV) 6 and 11, but the role of their genomic variants in the disease's clinical course is unclear. This study investigated whether long-term persistence of a particular HPV genotype, subtype or genomic variant influences the RRP clinical course. HPV genotyping was performed in paired baseline and follow-up RRP laryngeal tissue specimens of 59 patients. HPV6 and HPV11 genomic variants were determined in paired tissue specimens taken at least 10 years apart in 20 selected patients. HPV was identified in 58/59 patients, most commonly HPV6 (40/58), followed by HPV11 (17/58). The most prevalent HPV genomic variant was HPV11 A2. HPV6 A and HPV6 B1 were most frequent in aggressive RRP. In all patients, identical HPV genomic variants were identified in both paired specimens. RRP results from a long-term infection with the same HPV genomic variant that can be identified decades after disease onset. We report the longest duration of genetically confirmed persistent HPV infection in peer-reviewed literature, during a 44-year interval in a patient with HPB6 B1. This study suggests that infection with a particular HPV genotype, subtype, or genomic variant does not significantly influence the clinical course of RRP. HPV genomic variant human papillomaviruses laryngeal papilloma persistence recurrent respiratory papillomatosis HPV genomska različica humani papiloma virusi papiloma grla vztrajnost ponavljajoča se respiratorna papilomatoza true false true Angleški jezik Slovenski jezik Neznano 2026-06-11 15:11:23 2026-06-11 15:11:23 2026-06-12 03:54:47 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 11. 2024; str. 1-10 iss. 11, [article no.] e70060 Vol. 96 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 578 1096-9071 10.1002/jmv.70060 217039363 RAZ_Gluvajic_Dasa_2024.pdf RAZ_Gluvajic_Dasa_2024.pdf 1 D9D1CE613A416AC258F8020A8F07EB89 8353ef5163bdebbfe5fbd7aa3646eef242b26408e11692f7481d2e6fa18155f4 2947e926-6597-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45262 https://onlinelibrary.wiley.com/doi/10.1002/jmv.70060 1 0ce96943-6597-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45260 Univerzitetni klinični center Ljubljana 0 0 0