20.500.12556/DiRROS-30012 Retinal ganglion cell function and perfusion following intraocular pressure reduction with preservative-free latanoprost in patients with glaucoma and ocular hypertension (1) Background: Given the global prevalence of glaucoma and the crucial role of intraocular pressure (IOP) reduction in the management of the disease, understanding the immediate effects on retinal structure and function is essential. (2) Methods: This study aimed to assess the effects of preservative-free latanoprost on morphological and functional parameters in treatment-naïve patients with ocular hypertension and open-angle glaucoma. (3) Results: This study showed a significant reduction in IOP by an average of 30.6% after treatment with preservative-free latanoprost. Despite the significant reduction in IOP, no statistically significant changes were observed in the electroretinogram (ERG) nor the optical coherence tomography/angiography (OCT/OCTA) parameters compared to baseline. An exploration of the correlation between IOP changes and various parameters revealed a significant association solely with the macular IPL/INL plexus vessel density (VD) measured with OCTA. (4) Conclusions: This finding suggests a possible association between IOP reduction and changes in the macular microcirculation and provides valuable insights into the differential effects of latanoprost. Acknowledging the study limitations, this study emphasizes the need for larger, longer-term investigations to comprehensively assess the sustained effects of preservative-free latanoprost on both IOP and retinal parameters. In addition, exploring systemic factors and conducting subgroup analyses could improve personalized approaches to glaucoma treatment. electroretinogram optical coherence tomography optical coherence tomography angiography preservative-free latanoprost retinal ganglion cell elektroretinogram optična koherentna tomografija angiografija z optično koherentno tomografijo latanoprost brez konzervansov ganglijske celice mrežnice true false true Angleški jezik Slovenski jezik Neznano 2026-06-11 13:11:44 2026-06-11 13:11:44 2026-06-12 03:54:45 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 13. 5. 2024; str. 1-12 iss. 5, [article no.] 1226 Vol. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.7 2077-0383 10.3390/jcm13051226 195118595 RAZ_Daka_Qendrese_2024.pdf RAZ_Daka_Qendrese_2024.pdf 1 6B84EB4B786C2D84CB1FB763F55136DC 8a28d399927b7eeaf3cf271f700a7eb874613114546359b954a98596a7ae6123 87a7846b-6586-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45232 https://www.mdpi.com/2077-0383/13/5/1226 1 5574dcf5-6586-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45231 Univerzitetni klinični center Ljubljana 0 0 0