20.500.12556/DiRROS-29990 Association between autism spectrum disorder, trace elements, and intracranial fluid spaces Autism spectrum disorder (ASD) belongs to the group of complex developmental disorders. Novel studies have suggested that genetic and environmental factors equally affect the risk of ASD. Identification of environmental factors involved in the development of ASD is therefore crucial for a better understanding of its etiology. Whether there is a causal link between trace elements, brain magnetic resonance imaging (MRI), and ASD remains a matter of debate and requires further studies. (2) In the prospective part of the study, we included 194 children, including an age-matched control group; in the retrospective study, 28 children with available MRI imaging were included. All children had urine analysis of trace elements performed. In those with available brain MRI, linear indexes for the ventricular volumes were measured and calculated. (3) We found the highest vanadium, rubidium, thallium, and silver levels in children with ASD. These elements also correlated with the estimated ventricular volume based on MRI indexes in children with ASD in the subanalysis. However, the severity of the deficits did not correlate with brain MRI indexes of our elements, except negatively with magnesium. (4) Trace elements have an impact on children with ASD, but further multi-centric studies are needed to explain the pathophysiological mechanisms. autism spectrum disorders trace elements ventricular indexes motnje avtističnega spektra elementi v sledovih ventrikularni indeksi true false true Angleški jezik Slovenski jezik Neznano 2026-06-11 09:26:52 2026-06-11 09:26:52 2026-06-12 03:54:41 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 6. 8. 2024; str. 1-16 issue 15, [article no.] 8050 Vol. 25 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.896 1422-0067 10.3390/ijms25158050 203689475 RAZ_Mlinaric_Matej_2024.pdf RAZ_Mlinaric_Matej_2024.pdf 1 814ECCC4E5FABD9EC0E6AD07DE07D0E7 1d8fe2a6c7b1daff4fc5c9fcf0c8b6cc67664a58c3f2f54c97282af768228a44 04f9b96b-6567-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45186 https://www.mdpi.com/1422-0067/25/15/8050 1 ebc890c3-6566-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45185 Univerzitetni klinični center Ljubljana 0 0 0