20.500.12556/DiRROS-29940 Elevated levels of serum muscle enzymes in the initial phase of tick-borne encephalitis Purpose: Since some patients with tick-borne encephalitis (TBE) have pronounced myalgias, and since myositis is reported in Flavivirus diseases such as dengue, we performed systematic search for abnormalities of muscle enzymes in a group of patients in whom the presence of tick-borne encephalitis virus (TBEV) RNA in the first phase of the disease was demonstrated and who developed second phase of TBE.Methods: Total leukocyte and platelet blood counts were determined routinely at the initial examination during the first and the second phase of TBE. Activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kin-ase (CK), myoglobin and troponin was determined from the available stored serum specimens; the first and second phase disease specimens were tested simultaneously.Results: Of 24 patients with biphasic course of TBE, 83% had leukopenia, 65% thrombocytopenia, 83% elevated AST and 4% elevated ALT level. Furthermore, 33% had elevated serum CK, 26% myoglobin and 22% troponin activity; at least one of the muscle enzymes was elevated in 42% of patients. Leukopenia, thrombocytopenia, elevated liver enzymes and elevations of CK and myoglobin were present in the initial phase but resolve later, while troponin abnor-malities were also found in the second phase of TBE.Conclusions: The present study exposes that in addition to previously known leukopenia, thrombocytopenia and increased liver enzymes activity, the initial phase of TBE is relatively often associated also with elevated muscle enzymes. Clinical relevance of these findings remains to be determined. tick-borne encephalitis muscle enzymes creatine kinase myoglobin troponin klopni encefalitis mišični encimi kreatin kinaza mioglobin troponin true false true Angleški jezik Slovenski jezik Neznano 2026-06-09 14:09:03 2026-06-09 14:09:03 2026-06-10 03:48:59 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 4. 2024; str. 504-509 iss. 6 Vol. 56 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579 2374-4243 10.1080/23744235.2024.2335349 193390083 RAZ_Bogovic_Petra_2024.pdf RAZ_Bogovic_Petra_2024.pdf 1 961A65F0CD95C43C5D9F0733B6D35FD5 309a4c03c07bfa997cf542658e92215c5afa4df94a806189ced52f6d40c148db 3042bffb-63fc-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45091 https://www.tandfonline.com/doi/full/10.1080/23744235.2024.2335349 0 03636078-63fc-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45090 Univerzitetni klinični center Ljubljana 0 0 0