20.500.12556/DiRROS-29917 The efficacy of cysteamine as a melasma therapy a systematic review of trial studies Melasma is a chronic and refractory hyperpigmentation disorder that predominantly affects women and individuals with darker skin tones. Treatment remains challenging due to issues related to efficacy, side effects, and high recurrence rates. Cysteamine is a depigmenting agent that has demonstrated promising outcomes in melasma management with minimal adverse effects. This study evaluates the effectiveness of cysteamine as a treatment for melasma. A systematic review was conducted using databases from PubMed, Google Scholar, and ScienceDirect, including articles published over the past 10 years (2013–2023). Eight studies met the inclusion criteria for this review. Cysteamine showed good therapeutic efficacy, reflected in reductions in the melasma area and severity index (MASI) ranging from 1.5 to 10.07, with a mean decrease of 5.73. No severe adverse effects were reported, and only mild reactions such as erythema, itching, irritation, dry skin, tingling, and burning sensations were noted. Overall, cysteamine is demonstrated to be an effective and safe therapy for melasma, offering satisfactory clinical improvement with minimal side effects. cysteamine hyperpigmentation MASI melasma melazma cisteamin hiperpigmentacija kožne bolezni redka kožna bolezen true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:38:26 2026-06-09 08:52:39 2026-07-05 22:56:28 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 205-209 issue 4 Vol. 34 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-07-21 2025-11-07 2025-12-01 616.5-003.829 1318-4458 10.15570/actaapa.2025.36 276713731 RAZ_Kusumawardani_Arie_2025.pdf RAZ_Kusumawardani_Arie_2025.pdf 1 8AD2CA6F73B50EA6DF359CA8F4CB9F62 7819ca0b71526a717e7a0dcf5345741ea8a526808c0bf41b5bd16b05fad08bfa e7ca9bf1-63cf-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45012 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.36/actaapa.2025.36.pdf 0 3c05572a-6ae0-11f1-be3d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45877 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0