20.500.12556/DiRROS-29916 Zebrafish as a new approach methodology (NAM) in dermatology current research and the regulatory landscape focusing on sustainable development goals The conventional dependence on mammalian models in dermatological research is increasingly subject to ethical and sustainability-focused scrutiny, prompting a transition toward new approach methodologies (NAMs). Within this paradigm, zebrafish (Danio rerio) have surfaced as a persuasive alternative due to their genetic and physiological congruence with human skin, optical clarity during early developmental stages, accelerated life cycle, prolific reproductive capacity, and economically viable maintenance. This review describes recent research using zebrafish models in dermatology, including skin pigmentation disorders, barrier function, wound healing and regeneration, pharmacological discovery, genetic and inflammatory skin conditions, and melanoma. By examining the research, ethical, and logistical merits of zebrafish NAMs, this review emphasizes their contribution to fostering more humane and efficient research frameworks. Such integration also aligns with various United Nations Sustainable Development Goals (SDGs) 3, 9, 12, 13, 14, and 17, particularly regarding the accessible biomedical innovation in low- and middle-income countries (LMICs). The review also recognizes ongoing challenges, such as regulatory fragmentation and inconsistent validation of dermatological endpoints, which impede widespread translational acceptance. It concludes by presenting strategic recommendations for international collaboration, targeted financial support, cross-sector partnerships, and regulatory harmonization to realize the potential of zebrafish-based NAMs in dermatological research. zebrafish dermatology new approach methodologies sustainable development goals low- and middle-income countries zebrice navadna cebrica dermatologija metodologija z ovimi pristopi cilji trajnostnega razvoja raziskave true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Neznano 2026-06-09 08:38:24 2026-06-15 16:08:41 2026-06-18 09:41:17 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 193-202 issue 4 Vol. 34 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-07-14 2025-11-19 2025-12-01 616.5 1318-4458 10.15570/actaapa.2025.35 276712451 RAZ_Mukherjee_Sourik_2025.pdf RAZ_Mukherjee_Sourik_2025.pdf 1 F649D12947D8CF687947F779CFD2CD38 3b888574f543c331b5c19a4c3ca3040e9c28c1b1081b5e4957d49d920a121425 b12f8a9d-68c3-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45487 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.35/actaapa.2025.35.pdf 0 b50992a8-6ae0-11f1-be3d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45878 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0