20.500.12556/DiRROS-29910 Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris a randomized controlled trial Introduction: Acne vulgaris (AV) is a chronic inflammatory dermatosis predominantly affecting adolescents and young adults. Oxidative and nitrosative stress, marked by elevated nitric oxide (NO) and interleukin (IL)-1α, contributes to AV pathogenesis. Glutathione, a key antioxidant, may attenuate oxidative and nitrosative stress and modulate inflammatory pathways. This study investigates the effectiveness of oral glutathione supplementation on serum NO and IL-1α concentrations, and clinical improvement in mild to moderate AV patients. Methods: A randomized controlled trial was conducted involving 40 subjects diagnosed with mild to moderate AV. Participants were randomized to receive either 500 mg oral glutathione (n = 22) or placebo (n = 18) once daily for 4 weeks. Clinical severity of AV was assessed utilizing the Lehmann criteria. Serum levels of NO and IL-1α were measured at baseline and week 4. Results: At week 4, reductions in serum NO and IL-1α concentrations were observed in the glutathione group; however, these changes did not reach statistical significance (p > 0.05). Clinical improvement occurred in seven subjects (31.8%) in the glutathione group, with a reduction from moderate to mild severity. No adverse reactions were reported. Conclusions: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findings. acne vulgaris oxidative stress nitric oxide glutathione interleukin-1α akne vulgaris oksidativni stres dušikov oksid glutation interlevkin-1α true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:38:15 2026-06-15 19:33:43 2026-07-05 23:05:39 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 95-99 issue 3 Vol. 34 Sep. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-03-01 2025-07-02 2025-09-01 616.5:579 1318-4458 10.15570/actaapa.2025.23 260313347 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.23/actaapa.2025.23.pdf 1 cbfdda18-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45009 RAZ_Mawu_Ferra_Olivia_2025.pdf RAZ_Mawu_Ferra_Olivia_2025.pdf 1 DF3411288159FE2F0713499E046E6DCB 2bc56e81304997121286e3f62035229ebbdcf8c04a180bf2ceb9b452e3607e42 7d0d1f8b-68e0-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45497 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0