20.500.12556/DiRROS-29907 A case report of lymphomatoid papulosis uncovering a rare diagnosis from a common finger ulcer Lymphomatoid papulosis (LyP) is a rare, chronic CD30+ cutaneous lymphoproliferative disorder characterized by recurrent, selfhealing papulonodular lesions. Despite its benign clinical course, LyP histologically resembles malignant lymphomas, necessitating careful differentiation. A 42-year-old woman presented with a 3-year history of recurring ulcerated papulonodular lesions on her index finger. Histopathological examination revealed atypical CD30+ lymphoid proliferation, confirming LyP type A. Immunohistochemical analysis was positive for CD2, CD4, CD30, and multiple myeloma oncogene 1, while systemic malignancy was excluded. The patient was treated with low-dose methotrexate (15 mg/week), leading to symptom improvement. LyP is classified into five histological subtypes (A–E) and is often misdiagnosed due to its overlap with inflammatory and neoplastic conditions. While the condition typically resolves spontaneously, it is associated with an increased risk of secondary lymphomas, including mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. Accurate diagnosis relies on clinical presentation, histopathological evaluation, and immunophenotyping. Awareness of LyP’s clinical and pathological features is essential for appropriate management and surveillance. lymphomatoid papulosis CD30+ lymphoproliferative disorders cutaneous T-cell lymphoma dermatopathology limfomatoidna papuloza limfoproliferativne motnje kožni T-celični limfom dermatopatologija true false true Angleški jezik Slovenski jezik Neznano 2026-06-09 08:38:10 2026-06-15 20:20:29 2026-06-16 03:54:37 0000-00-00 00:00:00 2025 0 0 str. 151-154 issue 3 Vol. 34 Sep. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-09-01 616.5:579 1318-4458 10.15570/actaapa.2025.2 260312323 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.2/actaapa.2025.2.pdf 1 c9146cbd-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45006 RAZ_Kurmuş_Gokce_Işıl_2025.pdf RAZ_Kurmuş_Gokce_Işıl_2025.pdf 1 922D468D2D08C1F210CF9CB227640F35 6fe4725bec3bb04f1b135e7b95a4e8c86a6e9e3de2755563727342283ddf3a9b 197f3e68-68e7-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45511 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0