20.500.12556/DiRROS-29906 Oral lichen planus key features of etiopathogenesis, diagnosis, and management Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of unknown etiology. It is assumed that a genetic predisposition contributes to the development of the disease and influences the patient’s response to various etiological factors such as autoimmune reactions to epithelial antigens, microorganisms, and stress. Immunopathogenesis is primarily driven by cellmediated immune mechanisms, with T lymphocytes playing a central role. The clinical presentation of OLP is varied, and multiple clinical forms can occur in the same patient. OLP is categorized into six clinical types: reticular, papular, and plaque-like (hyperkeratotic variants), and atrophic, erosive, and bullous (erosive variants). The histopathological diagnosis of OLP is unique. Continuous follow-up of patients is crucial because OLP is considered an oral potentially malignant disorder (OPMD). Reported rates of malignant transformation vary, with a pooled estimate of 1.43% for OLP and 5.13% for OLP with dysplasia. Patient education plays a crucial role in treatment initiation and planning. A personalized treatment approach focuses on controlling inflammation and relieving symptoms such as pain and burning. Treatment should be individualized according to disease severity, subtype, and patient response, with constant monitoring for possible malignant transformation and comorbidities. etiopathogenesis clinical features malignant transformation oral lichen planus treatment etiopatogeneza klinične značilnosti maligna transformacija oralni lichen planus zdravljenje true false true Angleški jezik Slovenski jezik Neznano 2026-06-09 08:38:08 2026-06-15 20:18:34 2026-06-16 03:54:37 0000-00-00 00:00:00 2025 0 0 str. 109-115 issue 3 Vol. 34 Sep. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-09-01 616.5:579 1318-4458 10.15570/actaapa.2025.21 260285443 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.21/actaapa.2025.21.pdf 1 c7fbf4a4-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45005 RAZ_Glavina_Ana_2025.pdf RAZ_Glavina_Ana_2025.pdf 1 070FBFBEC517C09820AB66FFE1259510 6c86814d807b3a2eeca2a58ea7c6897bf1f097ed5d7006a24b163f2038bc0949 c11f9248-68e6-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45510 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0