20.500.12556/DiRROS-29897 Effects of oral minoxidil on serum VEGF and hair regrowth in androgenetic alopecia Introduction: Androgenetic alopecia (AGA) is a common hair loss condition characterized by follicular miniaturization. Vascular endothelial growth factor (VEGF) plays a key role in promoting angiogenesis and supporting hair follicle growth. Oral minoxidil has been suggested to upregulate VEGF levels, enhancing hair regrowth. Methods: This prospective study included 50 participants divided into two groups: oral minoxidil (1 mg/day; n = 25) and control (n = 25). Serum VEGF levels were measured at baseline and after 12 weeks of treatment. Hair growth parameters, including hair count, diameter, shedding, and pull test results, were assessed systematically. Results: Baseline VEGF levels were similar between groups (p = 0.1873). Post-treatment, VEGF levels increased significantly in the minoxidil group (217.88 ± 22.65 pg/ml vs. 142.81 ± 23.14 pg/ml in the control, p < 0.0001). Hair count and diameter improved significantly (p < 0.0001 and p = 0.0040, respectively), with reductions in shedding and pull test results (p < 0.0001). Positive correlations were observed between VEGF and hair count (r = 0.9965), whereas shedding showed negative correlations (r = −0.5374). Conclusions: Oral minoxidil significantly enhances VEGF levels, promoting hair growth and reducing shedding. VEGF serves as a promising biomarker for assessing treatment effectiveness and understanding the angiogenic mechanisms involved in AGA. androgenetic alopecia hair regrowth vascular endothelial growth factor oral minoxidil hair follicle angiogenesis androgenetska alopecija ponovna rast las vaskularni endotelijski rastni faktor peroralni minoksidil angiogeneza lasnih mešičkov true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:37:51 2026-06-15 19:56:29 2026-07-05 23:12:44 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 7-12 issue 1 Vol. 34 Mar. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-12-09 2025-02-10 2025-03-01 616.5:579 1318-4458 10.15570/actaapa.2025.5 260113923 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.5/actaapa.2025.5.pdf 1 bdcad8d6-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44996 RAZ_Kawen_Ahmed_Abdulhussein_2025.pdf RAZ_Kawen_Ahmed_Abdulhussein_2025.pdf 1 E47D7ED5948BC86BD74E21F8BDD25EDE 31d274430de6254d1afa5da3661215779e0dff11e82f9eb39757a191b2acbc49 a30916de-68e3-11f1-aebd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45501 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0