20.500.12556/DiRROS-29893 Treatment of foreign body granulomas with combined enzyme therapy Introduction: Granulomas are focal aggregates of inflammatory cells that form in response to a persistent inflammatory stimulus. Available therapies include surgical and nonsurgical management, and current evidence is based on case series or case reports. Methods: Two case reports of foreign body granulomas treated with a combination of recombinant enzymes (hyaluronidase, collagenase, and lipase of bacterial origin) are presented. Results: Following three sessions of combined enzyme treatment with a scheduled protocol, both patients showed clinical improvement without any reported adverse events. Conclusions: Combined enzyme therapy is an effective, safe, minimally invasive, innovative approach for the treatment of foreign body granulomas. granuloma combined enzyme treatment collagenase hyaluronidase lipase granulom kombinirano encimsko zdravljenje kolagenaza hialuronidaza lipaza true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Neznano 2026-06-09 08:37:46 2026-06-09 09:11:35 2026-06-17 00:15:46 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 75-77 issue 2 Vol. 34 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-12-26 2025-03-27 2025-06-01 616.5:579 1318-4458 10.15570/actaapa.2025.17 259281155 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.17/actaapa.2025.17.pdf 1 ba6e0d7e-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44992 RAZ_Castelanich_Desiree_Giselle_2025.pdf RAZ_Castelanich_Desiree_Giselle_2025.pdf 1 5796430F5713323B9CD22DEF5FF82764 72bc7c14213814220deaaab2a7c803fa81e78843e884feb02c41051ac8290885 7ec04ca7-63d2-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45022 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0