20.500.12556/DiRROS-29890 Two cases of bizarre acquired localised hyperpigmentation disorders – similar yet different diagnostic challenges two case reports and a brief literature review Cutaneous pigmentation disorders are one of the leading causes of dermatological consultation globally. Hyperpigmentation disorders constitute a group of distinct medical conditions that may be either congenital and associated with various concurrent comorbidities, or acquired due to cutaneous, environmental, or systemic conditions or factors. Due to numerous causes and an often atypical clinical picture, diagnosis can be challenging. Furthermore, although the changes in skin color are not inherently harmful, they can result in significant cosmetic disfigurement and have psychological and social repercussions, particularly given that some hyperpigmentation is irreversible due to the limited effectiveness of current treatments. This article presents two cases exhibiting somewhat similar but different acquired localized hyperpigmentation. We review the current literature with emphasis on the diagnostic approach to this entity and specific acquired hyperpigmentation disorders, in particular drug-induced and paraneoplastic. We emphasize the importance of interdisciplinary cooperation among different specialists, particularly in complicated cases and those that accompany systemic diseases. acquired hyperpigmentation drug-induced hyperpigmentation minocycline POEMS syndrome monoclonal plasma cell disorder pridobljena hiperpigmentacija hiperpigmentacija povzročena z zdravili minociklin POEMS sindrom monoklonska plazemska celična bolezen true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:37:42 2026-06-09 09:04:35 2026-07-09 03:56:45 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 89-93 issue 2 Vol. 34 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-11-06 2025-03-15 2025-06-01 616.5:579 1318-4458 10.15570/actaapa.2025.18 243115267 actaapa.2025.18.pdf actaapa.2025.18.pdf 1 B3471F88365751C60D0D69996FAF2876 bdb695d9684b20e19415115fa7ebed2ae5863a84af366e150389c453891416f2 bf3dfdd3-7aab-11f1-bd8a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47389 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.18/actaapa.2025.18.pdf 1 b85d1576-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44989 Združenje slovenskih dermatovenerologov Univerzitetni klinični center Ljubljana Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0