20.500.12556/DiRROS-29889 Cutaneous paradoxical inflammatory reaction of erythema induratum of Bazin to standard antituberculosis treatment Cutaneous tuberculosis (TBC) is rather rare and has diverse clinical presentations relative to host immunity and the number of bacilli present in the tissue. A group of cutaneous lesions called tuberculids represent a strong, delayed-type hypersensitivity reaction to mycobacteria. Among them, erythema induratum of Bazin (EIB) typically presents as tender erythematous nodules that ulcerate and are usually confined to the posterior aspects of the calves. Paradoxical reactions (PRs) to appropriate treatment involving the skin have mostly been described in the setting of miliary tuberculosis. These PRs are encountered in infectious and inflammatory diseases during the institution of appropriate treatment representing a worsening or relapse of disease under treatment or unmasking of subclinical disease. This case report describes a patient with EIB developing a necrotic PR shortly after initiation of antituberculosis therapy. The skin lesions cleared with a topical corticosteroid treatment and continued antituberculosis therapy. It is important to recognize cutaneous PR in the setting of treated cutaneous TBC and to reassure patients about the excellent outcome that can be achieved with continuation of treatment. erythema induratum of Bazin cutaneous tuberculosis tuberculids paradoxical reaction Bazinov eritem kožna tuberkuloza tuberkulidi paradoksna reakcija true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:37:40 2026-06-09 09:02:58 2026-07-05 23:30:30 0000-00-00 00:00:00 2025 0 Ljubljana 0 str. 85-87 issue 2 Vol. 34 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-09-25 2025-02-16 2025-06-01 616.5 1318-4458 10.15570/actaapa.2025.12 235524611 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.12/actaapa.2025.12.pdf 1 b711046a-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44988 RAZ_Pavlovic_Milos_2025.pdf RAZ_Pavlovic_Milos_2025.pdf 1 7BE26B0FB35A2EEC9134F5291DF0C91B b68648e22fea7fabdfa0188c99e7740b7a878720f0a02a110496f428e67cca4b 4b571e7c-63d1-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45017 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0