20.500.12556/DiRROS-29888 NTRK3-rearranged spindle cell neoplasm of the skin diagnostic pitfalls of an emerging entity, a case report Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-RSCNs) are an emerging category of rare soft tissue tumors recently recognized by the World Health Organization Classification of Soft Tissue and Bone Tumours. NTRK-RSCNs mostly affect the superficial soft tissues of the extremities and trunk, and they can occur across a broad age range. These tumors exhibit a wide morphologic spectrum, often mimicking other mesenchymal tumors. Recognition of NTRK-RSCNs is crucial for targeted therapy in selected cases, given the recent approval of kinase inhibitors. We describe the case of a 55-year-old male with an NTRK-RSCN located on the arm, harboring the novel fusion partner PPFIBP1::NTRK3, while providing additional clinical and morphological characteristics of this rare entity. kinase fusion neoplasm NTRK3 cutaneous spindle cell neoplasm soft tissue tumor case report kinazna fuzijska novotvorba kožna neoplazma vretenastih celic tumor mehkega tkiva prikaz primera true false true Združenje slovenskih dermatovenerologov Angleški jezik Slovenski jezik Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:37:38 2026-06-09 09:01:18 2026-07-05 23:31:03 0000-00-00 00:00:00 2025 0 Ljubljana 0 Soavtorji: Carla Di Loreto, Alenka Matjašič, Boštjan Luzar str. 147-149 issue 3 Vol. 34 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-11-09 2024-12-29 2025-01-01 616-006 1318-4458 10.15570/actaapa.2025.3 233228547 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.3/actaapa.2025.3.pdf 1 b5f0e8ad-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44987 RAZ_Coutada_Andreia_2025.pdf RAZ_Coutada_Andreia_2025.pdf 1 44FD6D98A598F80CAFEC2332200361E3 d01132df796cadfcffc54e8ed046535fe4ad84370b8e0a00ec4ca07e7c8f3dff 113e8457-63d1-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45016 Združenje slovenskih dermatovenerologov Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0