20.500.12556/DiRROS-29885 Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder a case report and literature review Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder (PCSM-LPD) is characterized by a slow-growing and asymptomatic solitary plaque or tumor, usually involving the head, neck, or upper extremities. The diagnosis is established based on clinical presentation, histopathological features including pleomorphic morphology and CD4-positive immunophenotype of neoplastic T lymphocytes, and molecular analysis showing clonally rearranged T-cell receptor (TCR) genes. Plaques typical of mycosis fungoides are essentially absent. Treatment options include surgical excision, radiotherapy, and topical or intralesional steroids. Because the disease is indolent, aggressive diagnostic tests and systemic treatments are not recommended. We present a case of PCSM-LPD in a previously healthy young man that spontaneously regressed after a biopsy. primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder primary cutaneous lymphoma T-cell lymphoma lymphoproliferative disorder spontaneous regression primarna kožna CD4-pozitivna limfoproliferativna motnja iz malih ali srednje velikih celic T primarni kožni limfom T-celični limfom limfoproliferativna motnja spontana regresija true false true Združenje slovenskih dermatovenerologov Angleški jezik Ni določen http://dx.doi.org/10.15570/actaapa.2024.29 Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). Neznano 2026-06-09 08:37:34 2026-06-09 08:55:35 2026-07-09 03:56:44 0000-00-00 00:00:00 2025 0 Ljubljana 2025 str. 79-82 issue 2 Vol. 34 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-09-16 2024-10-11 2025-06-01 616.5 1318-4458 10.15570/actaapa.2024.29 220499203 actaapa.2024.29.pdf actaapa.2024.29.pdf 1 FFA6837544A02CB88CBBAA547906EB00 d596bb6639294d7944d3e1ac72ddad25732ce3f13d707e5f9dcb19bebd4edbc6 82867742-7aae-11f1-bd8a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=47396 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2024.29/actaapa.2024.29.pdf 1 b3424371-63cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44984 Združenje slovenskih dermatovenerologov Univerzitetni klinični center Ljubljana Acta dermatovenerologica Alpina, Panonica et Adriatica 0 0 0