20.500.12556/DiRROS-29807 Impact of preventive substrate catheter ablation on implantable cardioverter-defibrillator interventions in patients with ischaemic cardiomyopathy and infarct-related coronary chronic total occlusion Aims: Primary prevention patients with ischaemic cardiomyopathy and chronic total occlusion of an infarct-related coronary artery (CTO) are at a particularly high risk of implantable cardioverter-defibrillator (ICD) therapy occurrence. The trial was designed to evaluate the efficacy of preventive CTO-related substrate ablation strategy in ischaemic cardiomyopathy patients undergoing primary prevention ICD implantation. Methods and results: The PREVENTIVE VT study was a prospective, multicentre, randomized trial including ischaemic patients with ejection fraction ≤40%, no documented ventricular arrhythmias (VAs), and evidence of scar related to the coronary CTO. Patients were randomly assigned 1:1 to a preventive substrate ablation before ICD implantation or standard therapy with ICD implantation only. The primary outcome was a composite of appropriate ICD therapy or unplanned hospitalization for VAs. Secondary outcomes included the primary outcome's components, the incidence of appropriate ICD therapies, cardiac hospitalization, electrical storm, and cardiovascular (CV) mortality. Sixty patients were included in the study. During the mean follow-up of 44.7 ± 20.7 months, the primary outcome occurred in 5 (16.7%) patients undergoing preventive substrate ablation and in 13 (43.3%) patients receiving only ICD [hazard ratio (HR): 0.33; 95% confidence interval (CI): 0.12-0.94; P = 0.037]. Patients in the preventive ablation group also had fewer appropriate ICD therapies (P = 0.039) and the electrical storms (Log-rank: P = 0.01). While preventive ablation also reduced cardiac hospitalizations (P = 0.006), it had no significant impact on CV mortality (P = 0.151). Conclusion: Preventive ablation of the coronary CTO-related substrate in patients undergoing primary ICD implantation is associated with the reduced risk of appropriate ICD therapy or unplanned hospitalization due to VAs catheter ablation implantable cardioverter-defibrillator ischaemic cardiomyopathy ventricular arrhythmia true false true Angleški jezik Ni določen Neznano 2026-06-05 14:38:30 2026-06-05 14:38:30 2026-06-06 03:58:35 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 5. 8. 2024; Str. 1-10 iss. 5, [article no.] euae109 Vol. 26 Jun. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1532-2092 10.1093/europace/euae109 203664387 RAZ_Zizek_David_2024.pdf RAZ_Zizek_David_2024.pdf 1 DDC83636767D69F6C9FC3721340FB92B 921baf35ee0d716659c74923de6f0b9f8f7ea716e1c76c05ea60cfd729f2f4ad 024d3b6d-60dc-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44815 https://academic.oup.com/europace/article/26/5/euae109/7657748 0 774ad232-60db-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44814 Univerzitetni klinični center Ljubljana 0 0 0