20.500.12556/DiRROS-29803 Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease. TBEV tick-borne encephalitis (TBE) TBEV-specific T-cells disease severity outcome TBEV klopni encefalitis TBEV-specifične T-celice raznolikost bolezni izid true false true Angleški jezik Slovenski jezik Neznano 2026-06-05 13:01:25 2026-06-05 13:01:25 2026-06-06 03:58:35 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 14. 3. 2024; str. 1-10 iss. 1, [article no.] 2317909 Vol. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2222-1751 10.1080/22221751.2024.2317909 189011971 RAZ_Aregay_Amare_2024.pdf RAZ_Aregay_Amare_2024.pdf 1 C86B86112046F463476F978B7A71BD67 e6485f7c79bd1b18af5cb94e6404aea28ea40fcd845d8b709a2a8db8502d35e5 11373e65-60ce-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44807 https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2317909 1 e75515bf-60cd-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44806 Univerzitetni klinični center Ljubljana 0 0 0