20.500.12556/DiRROS-29757 Clinical characteristics and outcomes of tympanomastoid paragangliomas a report from Slovenia Background: Head and neck paragangliomas are neuroendocrine tumors that typically originate from the parasympathetic nervous system and are predominantly non-secretory. Their clinical manifestations result from their mass effect on the surrounding tissues. The approach to treating these tumors depends on factors such as their location, size, impact on adjacent structures, and the patient’s overall health and preferences. (2) Methods: A retrospective analysis of the management of temporal bone paraganglioma classes A and B (according to the modified Fisch classification) was performed at the University Medical Centre, Ljubljana, between 2011 and 2023. (3) Results: We analyzed 23 cases, 19 of which underwent surgery; complete tumor removal was achieved in 18 of them. Four patients were irradiated due to tumor progression to class C. Three of these four patients initially refused surgery and were treated with radiotherapy (RT) 7, 13, and 18 years after diagnosis. In the fourth patient, complete surgical resection was not achieved and she was treated with RT four years after surgery, due to the growth of the tumor to class C. The average follow-up time from diagnosis was 8.9 years (median 6 years; range 1–26 years). (4) Conclusions: The surgical treatment of patients with class A and B paragangliomas is effective and safe. In cases where surgery is refused but the tumor continues to grow to class C, RT is an alternative and efficient method of controlling tumor growth. paraganglioma jugulotympanic tympanic treatment true false true Angleški jezik Ni določen Neznano 2026-06-04 14:09:33 2026-06-04 14:09:34 2026-06-05 04:05:59 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 9. 2024; str. 1-12 no. 18; ǂ[article no.] ǂ3178 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2072-6694 10.3390/cancers16183178 209370371 RAZ_Hribar_Manja_2024.pdf RAZ_Hribar_Manja_2024.pdf 1 13BE54F84D4A799B6C2DF0FAA530602F d90bf0c28c9fa26b7e21042222bfbe5bd2d04c264ffe2b5b7eb635bbc1747b8d 60409439-600e-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44729 https://www.mdpi.com/2072-6694/16/18/3178 1 413fb0e4-600e-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44728 Univerzitetni klinični center Ljubljana 0 0 0