20.500.12556/DiRROS-29749 A randomized, placebo-controlled study of chitosan gel for the treatment of chronic diabetic foot ulcers (the CHITOWOUND study Introduction: To assess the efficacy of a chitosan-based gel (ChitoCare) for the treatment of non-healing diabetic foot ulcers (DFUs). Research design and methods: Forty-two patients with chronic DFUs were randomized to the ChitoCare or placebo gel for a 10-week treatment period and 4-week follow-up. The primary study end point was the rate of complete wound closure at week 10, presented as relative rate. Results: Thirty patients completed the 10-week treatment and 28 completed the 4-week follow-up. The ChitoCare arm achieved 16.7% complete wound closure at week 10 vs 4.2% in the placebo arm (p=0.297), 92.0% vs 37.0% median relative reduction in wound surface area from baseline at week 10 (p=0.008), and 4.62-fold higher likelihood of achieving 75% wound closure at week 10 (p=0.012). Based on the results of the Bates-Jensen Wound Assessment Tool, the wound state at week 10 and the relative improvement from the baseline were significantly better (median 20 vs 24 points, p=0.018, and median 29.8% vs 3.6%, p=0.010, respectively). Conclusions: ChitoCare gel increased the rate of the DFU healing process. Several secondary end points significantly favored ChitoCare gel. clinical study diabetes complications diabetic foot wound healing klinične študije zapleti sladkorne bolezni celjenje ran true false true Angleški jezik Slovenski jezik Neznano 2026-06-04 12:56:10 2026-06-04 12:56:11 2026-06-05 04:05:57 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 6. 2024; 10 str. no. 3, [article no.] e004195 Vol. 12 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379-008.64-06:616.7+616-003.93 2052-4897 10.1136/bmjdrc-2024-004195 199834883 RAZ_Slivnik_Matevz_2024.pdf RAZ_Slivnik_Matevz_2024.pdf 1 1762876DB02A702ACEE591F5B1CE7900 d5701990d637a9f3042df1bd359b09a15f5510cb6009117876a44de50323da43 2b50f1a4-6004-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44712 https://drc.bmj.com/content/12/3/e004195.full 1 0087d67f-6004-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44711 Univerzitetni klinični center Ljubljana 0 0 0