20.500.12556/DiRROS-29726 Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome Introduction: Cholecystokinin (CCK) is involved in several metabolic pathways and CCK agonist are considered as potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor genes (CCKAR and CCKBR, respectively) may modify its biological actions, we investigated the impact of CCKAR and CCKBR genetic variability on anthropometric and metabolic parameters in patients with PCOS. Material and methods: Our cross-sectional study included 168 patients with PCOS and 82 healthy female controls genotyped for polymorphisms in CCKAR (rs6448456 and rs1800857) and CCKBR (rs2929180, rs1800843, rs1042047 and rs1042048) genes. Results: The investigated polymorphisms were not associated with anthropometric characteristics of patients with PCOS, however, among healthy controls carriers of at least one polymorphic CCKBR rs1800843 allele had bigger waist circumference (p=0.027) and more visceral fat (p=0.046). Among PCOS patients carriers of at least one polymorphic CCKAR rs6448456 C allele had significantly higher total blood cholesterol and LDL, and significantly lower blood glucose levels after 30, 60 and 90 minutes of the oral glucose tolerance test (all p<0.05). Healthy controls with at least one polymorphic CCKAR rs1800857 C allele were less likely to have high metabolic syndrome burden (p=0.029). Conclusions: Genetic variability in CCKAR affects lipid profile and post-load glucose levels in patients with PCOS and is associated with metabolic sydrome burden in healthy young women. Further investigation of the role of genetic variability in CCKAR and CCKBR could contribute to development of individually tailored treatment strategies with CCK receptor agonists. polymorphism PCOS cholecystokinin polimorfizem PCOS holecistokinin true false true Angleški jezik Slovenski jezik Neznano 2026-06-03 15:17:20 2026-06-03 15:17:20 2026-06-04 04:04:46 0000-00-00 00:00:00 2024 0 0 str. 1993-2001 iss. 6 Vol. 20 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 1734-1922 10.5114/aoms/150867 114139395 RAZ_Drnovsek_Eva_2024.pdf RAZ_Drnovsek_Eva_2024.pdf 1 E84E0372F7C06AD1C7170DAA1628347B 2c1e262c7d6423fc2bb7cb368d11ff9331a5e2b142f0e1523859f513d4a3dde0 aa0cad13-5f4e-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44666 https://www.archivesofmedicalscience.com/Genetic-variability-in-the-cholecystokinin-A-receptor-affects-lipid-profile-and-glucose,150867,0,2.html 1 8ed3b2e4-5f4e-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44665 Univerzitetni klinični center Ljubljana 0 0 0