20.500.12556/DiRROS-29721 The Influence of COVID-19 on antimicrobial resistance trends at a secondary care hospital in Slovenia an Interrupted Time Series Analysis We analyzed data from seven years, accounting for 441,149 patient days. The incidence density of multidrug-resistant bacteria (MDR) burden and infection was reported per 1000 patient days. Results. During COVID-19, a significant increase in the mean incidence density of the total MDR burden from 4.93 to 5.81 per 1000 patient days was observed (p = 0.007). On the other hand, the mean incidence density of MDR infections decreased from 1.61 to 1.29 per 1000 patient days (p = 0.019). Using the interrupted time series analysis, the same trends were observed, namely the overall increasing trend in MDR burden and the overall decreasing trend in MDR infections. This divergent trend is mainly due to similar trends in several Gram-negative MDR, namely ESBL-EC, ESBL-KP and CRE. Due to the increasing burden of MDR, it is necessary to strengthen AMR surveillance. In addition, strict infection prevention and control measures, and antimicrobial stewardship programs continue to be important. antimicrobial resistance COVID-19 Slovenia interrupted time series analysis protimikrobna odpornost COVID 19 Slovenija analiza prekinjene časovne serije true false true Angleški jezik Slovenski jezik Neznano 2026-06-03 14:54:42 2026-06-03 14:54:42 2026-06-04 04:04:46 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 11. 2024; Št. članka: 1033; 10 str. iss. 11, [article] 1033 Vol. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579 2079-6382 214692355 RAZ_Jeverica_Samo_2024.pdf RAZ_Jeverica_Samo_2024.pdf 1 352C946A629492269773A54A60111B99 7b48b14c329ba70498336416cecfe3f92c79aa3e3fafcb16a51d6ab364ce6bf0 8c9f62f1-5f4b-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44657 https://www.mdpi.com/2079-6382/13/11/1033 1 64b97915-5f4b-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44655 Univerzitetni klinični center Ljubljana 0 0 0