20.500.12556/DiRROS-29631 Review of the clinical electrooculogram - Part 1 mechanism of the light-rise The clinical electrooculogram (EOG) is the sole clinical electrophysiological test for assessing the function of the retinal pigment epithelium (RPE). However, despite several lines of investigation, the complete mechanism of the response has evaded a comprehensive description. The standard model implicates the rod photoreceptors and a signaling molecule termed the ‘light-rise substance’ that binds to an apical membrane ‘light-rise receptor’ or is transported across the membrane to elevate intracellular calcium concentration. The identity of the calcium activated chloride channel in the basolateral membrane was thought to be bestrophin, given the association of mutations in the hbest1 gene with Best Vitelliform Macular Dystrophy. However, recent findings have implicated a member of the anoctamin family as the calcium activated chloride channel with bestrophin regulating intracellular calcium in conjunction with the L-type calcium channel. How the changes in intracellular calcium are manifested as well as how the interaction with light in the dark-adapted state gives rise to the slow-dark and -light damped oscillations are yet to be described fully. This review summarizes the cellular mechanisms of the RPE that have been implicated in the generation of the light-rise and describes the likely candidates for the light-rise substance. A companion paper provides a summary of the bestrophinopathies and possible clinical modifications to enhance the EOG’s clinical utility. bestrophin light-peak retinal pigment epithelium anoctamin chloride calcium true false true Angleški jezik Ni določen Neznano 2026-06-02 08:34:42 2026-06-02 08:34:43 2026-06-03 03:56:34 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 4. 2026; str. 267-285 Vol. 152 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.7 1573-2622 10.1007/s10633-026-10103-z 275490051 RAZ_Constable_Paul_A._2026.pdf RAZ_Constable_Paul_A._2026.pdf 1 ADC436868534EBAA8AB6ECC6F2B64665 1a72a3b29b25af3acfb0c53a23e8257e9da0c762eaf6d4a0cc5a4cc96e59aa75 40f73cfc-5e4d-11f1-8e51-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44501 Univerzitetni klinični center Ljubljana 0 0 0