20.500.12556/DiRROS-29625 The impact of mild therapeutic hypothermia on platelet reactivity in comatose survivors of cardiac arrest with acute myocardial infarction treated with ticagrelor Background: The aim of the study was to assess the antiplatelet effect of ticagrelor in patients with myocardial infarction (MI) after out-of-hospital cardiac arrest (OHCA) treated with percutaneous coronary intervention (PCI) and mild therapeutic hypothermia (MTH) vs. MI patients without OHCA treated with PCI. Methods: The study was designed and performed as a phase IV, single-center, investigator-initiated, prospective, observational study assessing the early pharmacodynamic effect (within first 24 h) of a ticagrelor loading dose (180 mg) in both groups of patients (MTH group vs. MI group). For assessment of ticagrelor pharmacodynamics Multiple Electrode Aggregometry (MEA) was applied. Results: Compared with the MTH group, platelet inhibition was persistently stronger in the MI group over the entire observation period (up to 24 h), with the highest differesnce at 4 hours after loading with ticagrelor (25.8 ± 26.4 vs. 75.8 ± 40.9 U, p = 0.002). As a consequence, there was a higher prevalence of high platelet reactivity in the MTH group, with the most explicit difference at 6 hours after the loading dose of ticagrelor (78% vs. 7%, p < 0.001). Conclusions: In comparison with patients treated with primary PCI for uncomplicated MI, the antiplatelet effect of ticagrelor in patients with MI complicated with OHCA, undergoing MTH and primary PCI, is attenuated and delayed. cardiac arrest myocardial infarction hypothermia ticagrelor pharmacodynamic platelets true false true Angleški jezik Ni določen Neznano 2026-06-01 14:37:07 2026-06-01 14:37:08 2026-06-02 03:48:27 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 5. 2026; str. 472-478 no. 3 Vol. 31 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12 1898-018X 10.5603/CJ.a2022.0029 278616579 RAZ_Umińska_Julia_Maria_2024.pdf RAZ_Umińska_Julia_Maria_2024.pdf 1 574FEA53A20737ED8CF5DCC008926046 a00e8ab97182ee4256ad5381614f173aceffe21fadaf26b8c04dbe99b23cfbcc cb3f211d-5db6-11f1-8e51-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44490 https://journals.viamedica.pl/cardiology_journal/article/view/85033 1 9cc0257f-5db6-11f1-8e51-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44489 Univerzitetni klinični center Ljubljana 0 0 0