20.500.12556/DiRROS-29415 Reliability and responsiveness of endoscopic indices for assessing Crohn’s disease postoperative recurrence in the PREVENT trial Background & Aims: Assessing endoscopic activity is integral in the management of postoperative Crohn’s disease (CD). We aimed to comprehensively characterize the reliability and responsiveness of different endoscopic instruments when used to assess postoperative CD activity. Methods: Ileocolonoscopy videos (n = 70) from the PREVENT (Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE ® [infliximab] and Placebo in the Prevention of Recurrence in Crohn’s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence) trial were reviewed by 3 blinded central readers. Disease activity was assessed using the Rutgeerts and modified Rutgeerts scores, POCER (postoperative Crohn's endoscopic recurrence) index, REMIND (groupe de REcherche sur les Maladies INflammatoires Digestives) score, Simple Endoscopic Score for Crohn’s Disease (SES-CD), and the Crohn’s Disease Endoscopic Index of Severity (CDEIS). Reliability was quantified by the intraclass correlation coefficient (ICC). Responsiveness was quantified using the win probability (WinP) defined as the probability that a patient in the treatment (infliximab) group had a better score than a patient in the placebo group. The neoterminal ileum, anastomosis, and distal colon were scored separately. Results: Interrater reliability was substantial for the Rutgeerts and modified Rutgeerts scores, ileal REMIND score, SES-CD, and CDEIS (ICC 0.74–0.80), moderate for the POCER index (ICC 0.49), and fair for the anastomotic REMIND score (ICC 0.30). A large degree of responsiveness was observed for the Rutgeerts and modified Rutgeerts scores, ileal REMIND score, SES-CD, and CDEIS (WinP 0.75–0.83). The degree of responsiveness for the POCER index and the anastomotic REMIND score was small (WinP 0.54 and 0.53, respectively). Estimates of index reliability and responsiveness were consistently lower when assessed at the anastomosis or distal colonic segment compared with the neoterminal ileum. Conclusions: Existing endoscopic indices are reliable and responsive for assessing postoperative CD activity in the neoterminal ileum, although are suboptimal for evaluation in the anastomosis or distal colonic segment. inflammatory bowel disease clinical trials endoscopy ileocolonic resection postoperative Crohn’s disease true false true Angleški jezik Ni določen Neznano 2026-05-18 11:28:45 2026-05-18 11:28:45 2026-05-19 03:54:39 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 9. 2025; str. 1393-1401 issue 5 Vol. 24 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.3 1542-7714 10.1016/j.cgh.2025.08.021 250795779 RAZ_Hanzel_Jurij_2026.pdf RAZ_Hanzel_Jurij_2026.pdf 1 F2CC7F4466595A15CBE38D2951DD5E99 cd4761d32aa6a3727b9292afd394d37f1bd50d525341ec4403abc5e6a207a9c4 1b2b87b4-529c-11f1-8a5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44097 Univerzitetni klinični center Ljubljana 0 0 0