20.500.12556/DiRROS-29331 Monoclonal annular lichenoid dermatitis of youth as a new entity a case report and review of the literature Annular lichenoid dermatitis of youth (ALDY) is a rare lichenoid dermatosis characterized by distinctive clinical and histopathological features. Its etiopathogenesis remains poorly understood, and previously reported cases have consistently demonstrated polyclonal T-cell receptor (TCR) gene rearrangements. We report a patient with clinical, histopathological, and immunohistochemical findings consistent with ALDY in whom molecular analysis revealed monoclonal T-cell receptor rearrangement within the skin lesions. To our knowledge, this represents the first reported case of ALDY demonstrating T-cell monoclonality. This novel finding expands the current understanding of the molecular spectrum of ALDY and raises the possibility that cases with monoclonal T-cell rearrangement may represent a distinct clinicopathological variant. Based on our findings, we tentatively propose the term monoclonal annular lichenoid dermatitis of youth (MALDY) to describe this potential entity. Further studies are warranted to clarify its clinical significance and relationship to other cutaneous T-cell disorders. T-cell monoclonality annular lichenoid dermatosis youth cutaneous T-cell lymphoma dermatopathology true false true Angleški jezik Ni določen Neznano 2026-05-08 13:59:25 2026-05-08 13:59:25 2026-05-09 03:44:21 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira 30. 4. 2026; str. 1-12 iss. 9, [article no.] 3990 Vol. 27(9) 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1422-0067 10.3390/ijms27093990 276799235 RAZ_Tockova_Olga_2026.pdf RAZ_Tockova_Olga_2026.pdf 1 FD7DC855BA5ADDC6FC417931A45FB267 c30b4388aa5621109f07100dff0c0012703bd9630d1c3bcf74c84a5cbe6bf51e 7eb546f7-4ad5-11f1-8a5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43914 https://www.mdpi.com/1422-0067/27/9/3990 1 5ca1ab81-4ad5-11f1-8a5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43913 Univerzitetni klinični center Ljubljana 0 0 0