20.500.12556/DiRROS-29212 European prognosis evaluation of early-stage lung adenocarcinoma patterns after lobectomy versus segmentectomy based on clinical stage settings Objectives: To investigate the prognosis of peripheral early-stage lung adenocarcinoma patterns treated by lobectomy or segmentectomy. Methods: Retrospective multicentric cohort of patients with cT1a-bN0M0 lung adenocarcinoma who underwent lobectomy or segmentectomy with systematic lymph node dissection in 10 European centers (one per country) from 2015 to 2021. Overall survival (OS), disease-free survival (DFS), and lung cancer–specific death (LCSD) between both groups were assessed in entire dataset and in dataset of histologic aggressive patterns, before and after propensity score-matching (PSM). Prognostic risk factors were analyzed using parsimonious model Cox regression. Recurrences were assessed by linearized risks. Results: Lobectomy and segmentectomy were performed in 1029 (73.1%) and 377 (26.8%) patients, respectively. In total, 427 (30.3%) patients had at least 1 histologic aggressive (micropapillary or solid) pattern, and 88 patients (20.7%) underwent segmentectomy. OS, DFS, and LCSD rates were similar between patients who underwent lobectomy or segmentectomy, in both datasets, before and after PSM. In aggressive dataset, PSM, 5-year OS rates were lobectomy 88.0% (95% CI, 80.9-95.7%), segmentectomy 89.1% (95% CI, 82.2-96.6%), P = .8; 5-year DFS rates were lobectomy 79.8% (95% CI, 70.8-89.8%), segmentectomy 80.6% (95% CI, 71.6-90.6%), P = .6; and 5-year LCSD rates were lobectomy 6.0%, segmentectomy 7.8%, P = .8. Locoregional recurrence was not superior in patients who underwent segmentectomy in entire dataset (linearized risks: lobectomy 0.078, segmentectomy 0.073) and in aggressive dataset (linearized risks: lobectomy 0.036, segmentectomy 0.011) only in the unmatched cohorts. Aggressive histologic patterns impacted on only LCSD, and only when they were dominant. Conclusions: Segmentectomy seems comparable to lobectomy for patients with peripheral cT1a-bN0M0 lung adenocarcinoma even in case of histologic aggressive patterns. lobectomy lung adenocarcinoma segmentectomy patterns prognosis true false true Angleški jezik Ni določen Neznano 2026-04-24 14:06:19 2026-04-24 14:06:19 2026-04-25 03:53:42 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis z dne 18. 3. 2026; str. 1-11 [article no.] ǂ101687 Vol. 30 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-089:616.2 2666-2736 10.1016/j.xjon.2026.101687 272067075 RAZ_Lula_Lukadi_Joseph_2026.pdf RAZ_Lula_Lukadi_Joseph_2026.pdf 1 E19244756D65E1DF7520E9FC33923668 2b74acf2616234d78b90da8433536db7fcb82ba65dc35a373b69d37a39295901 28d4b822-3fd6-11f1-ad5f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43691 Univerzitetni klinični center Ljubljana 0 0 0