20.500.12556/DiRROS-29170 Association between the rs2279238 and rs12221497 of the LXRA gene variants and diabetic retinopathy in the Slovenian cohort Aim: To investigate whether the rs2279238 and rs12221497 variants in the liver X receptor alpha (LXRA) gene are associated with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Considering the involvement of LXRA in lipid metabolism and inflammatory pathways, we hypothesized that these genetic variants might participate in the pathogenesis of DR. Methods: 1554 unrelated Caucasians who had type 2 diabetes mellitus (T2DM) for more than 10 years were included. Patients were divided into two groups: the cases (with DR, 577 subjects) and the control group (without DR, 977 subjects). Genetic analysis was performed using the KASPar assay. Results: We found a significant association between the rs2279238 variant and DR. The participants with the TT or TC genotype were more likely to have DR in comparison with the CC genotype according to the dominant model of inheritance (95 % OR: 1.35 (1.05-1.74), p = 0.028). We did not find an association between the rs12221497 variant and DR. Conclusions: The rs2279238 variant in the LXRA gene is significantly associated with diabetic retinopathy (DR) in Caucasians with T2DM. Individuals carrying the TT or TC genotype have a higher risk of developing DR compared to those with the CC genotype. However, no association was found between the rs12221497 variant and DR. diabetic retinopathy LXRA rs12221497 rs2279238 T2DM variant diabetična retinopatija sladkorna bolezen tipa 2 varianta true false true Angleški jezik Slovenski jezik Neznano 2026-04-22 14:39:17 2026-04-22 14:39:17 2026-04-23 04:02:16 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 8. 2025; str. 1-4 Vol. 965, [article no.] 149665 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379 1879-0038 245286403 RAZ_Grbic_Emin_2025.pdf RAZ_Grbic_Emin_2025.pdf 1 02E738ACB40E47F95D099FA4BBFD1925 7ee4bec417a297b929bbcb1512775ed0c321283de8d58d5ea8b97de0ef4ffee0 a7501ca8-3e48-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43602 https://www.sciencedirect.com/science/article/pii/S0378111925004548?via%3Dihub 1 4864afd2-3e48-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43600 Univerzitetni klinični center Ljubljana 0 0 0