20.500.12556/DiRROS-29150 Perioperative bleeding understanding causes, mechanisms and novel management approaches Perioperative bleeding represents a significant clinical challenge that impacts patient outcomes, prolongs recovery times and increases healthcare costs. This multifactorial condition arises from various causes, including surgical factors, coagulopathies, and the use of anticoagulants and antiplatelet agents. The management of perioperative bleeding is further complicated by the increasing use of novel anticoagulants and the presence of congenital or acquired bleeding disorders. This review discusses the pathophysiology of coagulation, the mechanisms contributing to perioperative bleeding, and current management strategies, particularly in patients undergoing anticoagulation therapy, while also exploring emerging technologies and therapies such as hemoadsorption devices, novel anticoagulant reversal strategies, point-of-care testing and evolving anticoagulant adsorbers. Overall, our findings highlight the critical need for individualized, evidence-based management strategies, and further research to optimize perioperative anticoagulation protocols and improve surgical outcomes. perioperative bleeding anticoagulants antiplatelet drugs pooperativne krvavitva antikoagulantna zdravila antitrombotiki true false true Angleški jezik Slovenski jezik Neznano 2026-04-22 11:17:52 2026-04-22 11:17:52 2026-04-23 04:02:13 0000-00-00 00:00:00 2025 0 0 str. 29-42 iss. 7 Vol. 21 Jul. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 1334-5605 10.22514/sv.2025.094 241996035 RAZ_Taleska_Stupica_Gordana_2025.pdf RAZ_Taleska_Stupica_Gordana_2025.pdf 1 648ACF13F4A49CA4EE1D634E884F9BEA 696bc255e0838c1c36e197e5e5f5873c9c2e7db73ac915f181d1407081bb6e09 57fe6fc3-3e2c-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43563 Univerzitetni klinični center Ljubljana 0 0 0