20.500.12556/DiRROS-29106 Inflammation and perioperative cardiovascular events Abstract. Surgery and anesthesia induce a stress response that provokes increased sympathetic stimulation, secretion of cortisol, hypercoagulability, and systemic inflammatory response. All these homeostatic deteriorations, especially systemic inflammation, represent a risk for organ damage. Perioperative cardiac complications have an increasing impact on morbidity and mortality, not only in cardiovascular but also in non-cardiac surgery. Surgical procedures represent a potential trigger for systemic inflammation that causes secretion of proinflammatory cytokines, activation of neutrophils, and tissue damage. Also, increased levels of preoperative inflammatory markers predict perioperative cardiovascular events. Systemic inflammatory biomarkers increase during the first days after surgical procedures and decline within a few weeks. Besides contemporary traditional biomarkers (CRP, BNP), newer biomarkers, such as galectin-3, TNF-α, and various MiRNAs, can predict inflammatory response and related cardiac injury. Determination of inflammatory markers in the perioperative period could help identify patients at risk for cardiovascular events. The reduction in perioperative inflammatory response may improve surgical outcomes. Prevention and treatment of systemic inflammation can be achieved by optimization of surgical procedures, anesthetic regimen, and pharmacological agents, especially interleukin inhibitors. Determination of inflammatory biomarkers, along with prevention and treatment of inflammation, can improve perioperative cardiac risk reduction strategies. true false true Angleški jezik Ni določen Neznano 2026-04-21 10:12:00 2026-04-21 10:12:01 2026-04-22 04:04:11 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 10. 2025; str.: 1-13 Iss. 17 Vol. 14 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617 2073-4409 10.3390/cells14171362 252316931 RAZ_Poredos_Peter_2025.pdf RAZ_Poredos_Peter_2025.pdf 1 33D33276BB4E0930513A5E873F01F01E bc47c12c86fe6121d01b41a3e2ed7b280821493a9d806d3494d9ffdc64cd6734 df50e9b6-3d59-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43487 Univerzitetni klinični center Ljubljana 0 0 0