20.500.12556/DiRROS-29104 Targeting the NO-sGC-cGMP pathway mechanisms of action of vericiguat in chronic heart failure The recent advancements in the medical management of patients with chronic heart failure with reduced ejection fraction (HFrEF) is the soluble guanylate cyclase (sGC) stimulator, vericiguat. Clinical trials have demonstrated that vericiguat effectively lowers plasma levels of NT-proBNP and reduces the risk of cardiovascular death or hospitalization in HFrEF patients, making it a class IIb recommendation for patients with worsening heart failure despite receiving guideline-directed medical therapy. However, the precise pathophysiological mechanisms underlying these clinical benefits remain unexplored. This review aims to present the signalling pathways associated with maladaptive remodeling and heart failure progression that can be modulated by sGC stimulators, focusing on the antihypertrophic, antifibrotic, and anti-inflammatory effects of NO-sGC-cGMP signalling observed in preclinical studies. A better understanding of the mechanisms of action of sGC stimulators could optimize heart failure treatment strategies and enable tailoring of therapies to individual patient profiles. heart failure soluble guanylate cyclase stimulators vericiguat srčno popuščanje topni stimulatorji gvanilat ciklaze true false true Angleški jezik Slovenski jezik Neznano 2026-04-21 10:08:38 2026-04-21 10:08:39 2026-04-22 04:04:09 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 13. 11. 2025; str. 1-21 iss. 17, [article no.] 1400 Vol. 14 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2073-4409 10.3390/cells14171400 257143555 RAZ_Bajec_Tine_2025.pdf RAZ_Bajec_Tine_2025.pdf 1 392AD171B1A9E5805369A7BAA4273552 f4a103cb6e510cb73b97d508f758117c948e712675825a24b6e4a36d8030b4a7 64f0c681-3d59-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43485 https://www.mdpi.com/2073-4409/14/17/1400 1 4fe8b3af-3d59-11f1-a343-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43484 Univerzitetni klinični center Ljubljana 0 0 0