20.500.12556/DiRROS-29051 Effect of bleomycin hydrolase expression in tumor tissue on the therapeutic effectiveness of electrochemotherapy Electrochemotherapy (ECT) is a cancer treatment that combines application of short electrical pulses with chemotherapy drugs to improve their delivery into tumor cells. Bleomycin is one of the most effective drugs used in ECT, but its success can vary depending on the tumor type. One possible reason is the presence of bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin. In this study, we measured BLMH levels in different mouse tumor cell lines and tumors grown in animals. Thereafter we compared the levels of BLMH with tumor response to ECT and found a correlation with BLMH content, i.e., tumors with higher BLMH content responded poorly. These findings suggest that levels of BLMH could serve as a predictive marker for ECT effectiveness. Testing for BLMH before treatment may help personalize therapy and identify patients most likely to benefit from ECT. electrochemotherapy bleomycin hydrolase predictive biomarker murine models elektrokemoterapija hidrolaza bleomicina napovedni biološki označevalci modeli sesalcev true false true MDPI, Basel, Switzerland Basel, Switzerland Angleški jezik Slovenski jezik by Authors Neznano 2026-04-20 09:53:59 2026-04-20 09:53:59 2026-04-21 04:15:20 0000-00-00 00:00:00 2025 0 Basel 0 Nasl. z nasl. zaslona; Opis vira z dne 9. 1. 2026; str. 127-1-127-13 no. 1 Vol. 18 Jan. 2026 0000-00-00 Zaloznikova Objavljeno apc 2025-11-21 2025-12-29 2025-12-30 602 2072-6694 10.3390/cancers18010127 263366147 https://www.mdpi.com/2072-6694/18/1/127 1 19000482-3c8e-11f1-b8c8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43378 RAZ_Bogataj_Jan_2025.pdf RAZ_Bogataj_Jan_2025.pdf 1 7F4A99461303C6E3AF4336F6A2DFDCAC 87920551603ce4b647a17720b9973e2fd21a205bb92f877bc2d300b06209c597 a1917c21-3c8e-11f1-b8c8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43380 Onkološki inštitut Ljubljana 0 0 0